Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography : A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden

• Published in: Circulation (New York, N.Y.) Vol. 117; no. 19; pp. 2458 - 2466
• Main Authors: BALLANTYNE, Christie M, RAICHLEN, Joel S, NICHOLLS, Stephen J, ERBEL, Raimund, TARDIF, Jean-Claude, BRENER, Sorin J, CAIN, Valerie A, NISSEN, Steven E
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 13.05.2008
• Subjects: Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cholesterol, LDL - blood; Coronary Angiography - methods; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - drug therapy; Coronary heart disease; Coronary Stenosis - diagnosis; Coronary Stenosis - drug therapy; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Fluorobenzenes - administration & dosage; Fluorobenzenes - pharmacology; Heart; Humans; Male; Medical sciences; Middle Aged; Pyrimidines - administration & dosage; Pyrimidines - pharmacology; Rosuvastatin Calcium; Sulfonamides - administration & dosage; Sulfonamides - pharmacology; Treatment Outcome; Ultrasonography, Interventional; Angiography; Enzyme; drugs; Coronary artery; Enzyme inhibitor; Lipids; Cardiovascular disease; Statin derivative; Rosuvastatin; Coronary arteriography; Hypocholesterolemic agent; Coronary heart disease; Cholesterol; Vascular disease; coronary disease; Treatment; HMG-CoA reductase inhibitor; Atherosclerosis; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Atheroma; Ultrasound; Antilipemic agent
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.108.773747

Previous studies using quantitative coronary angiography have demonstrated that statin therapy slows the progression of coronary stenoses in proportion to average low-density lipoprotein cholesterol levels during therapy. However, no major statin monotherapy study has demonstrated either halted progression or regression of angiographic disease. A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID) assessed whether rosuvastatin could regress coronary atherosclerosis by intravascular ultrasound and quantitative coronary angiography. Intravascular ultrasound showed atheroma volume regression in a single coronary artery with <50% angiographic luminal narrowing. ASTEROID treated 507 coronary disease patients with rosuvastatin 40 mg/d for 24 months. Blinded quantitative coronary angiography analyses of percent diameter stenosis and minimum lumen diameter were performed for up to 10 segments of coronary arteries and major branches with >25% diameter stenosis at baseline. For each patient, the mean of all matched lesions at baseline and study end was calculated. There were 292 patients with 613 matched stenoses. Rosuvastatin reduced low-density lipoprotein cholesterol by 53.3% to 61.1+/-20.3 mg/dL and increased high-density lipoprotein cholesterol by 13.8% to 48.3+/-12.4 mg/dL. Mean+/-SD percent diameter stenosis decreased from 37.3+/-8.4% (median, 35.7%; range, 26% to 73%) to 36.0+/-10.1% (median, 34.5%; range, 8% to 74%; P<0.001). Minimum lumen diameter increased from 1.65+/-0.36 mm (median, 1.62 mm; range, 0.56 to 2.65 mm) to 1.68+/-0.38 mm (median, 1.67 mm; range, 0.76 to 2.77 mm; P<0.001). Rosuvastatin treatment for 24 months to average low-density lipoprotein cholesterol levels well below 70 mg/dL, accompanied by significant increases in high-density lipoprotein cholesterol, produced regression by decreasing percent diameter stenosis and improving minimum lumen diameter as measured by quantitative coronary angiography in coronary disease patients.