Three new 8,4'-type oxyneolignans from the seeds of Ziziphus jujuba mill and their antitumor studies

Mill. is a deciduous shrub, belonging to the Rhamnaceae family. Phytochemical investigation of seeds showed the presence of three undescribed 8,4'-type oxyneolignans ( ). Their structures were elucidated by comprehensive spectroscopic analyses. All isolated compounds were tested for antitumor a...

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Bibliographic Details
Published inNatural product research Vol. 37; no. 9; pp. 1573 - 1576
Main Authors Liu, Si-Yu, Gu, Bin
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Ltd 01.05.2023
Subjects
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antitumor activity
Antitumor agents
Cytotoxicity
Hepatoma
Humans
Lignans - chemistry
Rhamnaceae
Seeds
Seeds - chemistry
Toxicity
Ziziphus - chemistry
Ziziphus jujuba
8,4′-type oxyneolignans
Rhamnaceae
antitumor activity
Ziziphus jujuba Mill
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Summary:Mill. is a deciduous shrub, belonging to the Rhamnaceae family. Phytochemical investigation of seeds showed the presence of three undescribed 8,4'-type oxyneolignans ( ). Their structures were elucidated by comprehensive spectroscopic analyses. All isolated compounds were tested for antitumor activity against two human hepatoma cells (Hep3B and HepG2) and exhibited moderate cytotoxicity (IC : 33.79-49.62  M).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2023144