Inhibitory effect of a low dose of prednisone on PHA-induced Ia antigen expression by human T cells and on proliferation of T cells stimulated with autologous PHA-T cells

• Published in: Cellular immunology Vol. 80; no. 2; pp. 320 - 328
• Main Authors: Indiveri, F., Scudeletti, M., Pende, D., Barabino, A., Russo, C., Pellegrino, M.A., Ferrone, S.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.09.1983; Elsevier
• Subjects: Adult; Antibodies, Monoclonal; Antigens, Surface - genetics; Biological and medical sciences; Cells, Cultured; DNA Replication - drug effects; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes, MHC Class II; Humans; Immunobiology; Lymphocyte Activation - drug effects; Modulation of the immune response (stimulation, suppression); Phytohemagglutinins; Prednisone - pharmacology; Rosette Formation; T-Lymphocytes - immunology; Human; Cell proliferation; Steroid; Histocompatibility system; Mixed lymphocyte reaction; Cell-cell interaction; Prednisone; Autologous system; Phytohemagglutinin; Ia-System; Immunological method; Dose activity relation; Antigen; Immunomodulator; Immunosuppression; Immune stimulation; T-Lymphocyte; Reversibility; Kinetics
• ISSN: 0008-8749; 1090-2163
• DOI: 10.1016/0008-8749(83)90120-X

Administration of a small dose of prednisone markedly reduced (1) the PHA-induced expression of Ia antigens by T cells, (2) the stimulatory activity of Ia antigen-bearing T cells in autologous and allogeneic mixed lymphocyte reactions (MLRs), and (3) the proliferative response of T cells stimulated with autologous PHA-activated T cells or autologous or allogeneic non-T cells. The inhibitory effects of prednisone are reversible and are not detectable on T cells isolated from blood drawn 24 hr following prednisone administration. The kinetics of the prednisone-mediated inhibition of MLRs with autologous PHA-T cells is different from that of MLRs with autologous non-T cells. These data in conjunction with the information available in the literature suggest that the mechanisms underlying these two types of autologous MLRs are different.