A biological response modifier, PSK, inhibits reverse transcriptase in vitro

We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibiti...

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Published inBiochemical and biophysical research communications Vol. 149; no. 2; pp. 562 - 567
Main Authors Hirose, Kunitaka, Hakozaki, Michinori, Kakuchi, Junji, Matsunaga, Kenichi, Yoshikumi, Chikao, Takahashi, Massaaki, Tochikura, Tadafumi S., Yamamoto, Naoki
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 16.12.1987
Elsevier
Subjects
Acquired Immunodeficiency Syndrome - drug therapy
AIDS/HIV
Applied sciences
Coriolus versicolor
Dose-Response Relationship, Drug
Exact sciences and technology
HIV - drug effects
human immunodeficiency virus
Humans
Kinetics
Other techniques and industries
Proteoglycans - pharmacology
Proteoglycans - therapeutic use
Reverse Transcriptase Inhibitors
ddCTP
PSK
AIDS
[iO 2A)n] 46
ddNTP
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Summary:We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important in its anti-HIV effect as well as its inhibitory effect on the binding of HIV with lymphocytes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(87)90404-9