Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neost...

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Bibliographic Details
Published inBrain research Vol. 503; no. 2; p. 334
Main Authors Ingham, C A, Hood, S H, Arbuthnott, G W
Format Journal Article
LanguageEnglish
Published Netherlands 04.12.1989
Subjects
Aging - physiology
Animals
Corpus Striatum - growth & development
Corpus Striatum - ultrastructure
Dendrites - drug effects
Dendrites - physiology
Hydroxydopamines
Male
Medial Forebrain Bundle - drug effects
Medial Forebrain Bundle - physiology
Oxidopamine
Rats
Rats, Inbred Strains
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Summary:Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).
ISSN:0006-8993
DOI:10.1016/0006-8993(89)91686-7