Extracellular virulence factors of group B Streptococci

Group B Streptococcus (GBS) is the leading cause of severe bacterial infections in human newborn infants. Advances in streptococcal molecular genetics and refinement of in vitro and in vivo model systems of GBS disease have led to the discovery and characterization of several extracellular virulence...

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Bibliographic Details
Published inFrontiers in bioscience Vol. 9; no. 1-3; pp. 1794 - 1802
Main Authors Liu, George Yen-Hsi, Nizet, Victor
Format Journal Article
LanguageEnglish
Published United States 01.05.2004
Subjects
Humans
Infant, Newborn
Streptococcal Infections - microbiology
Streptococcus
Streptococcus agalactiae - pathogenicity
Virulence Factors - genetics
Virulence Factors - physiology
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Summary:Group B Streptococcus (GBS) is the leading cause of severe bacterial infections in human newborn infants. Advances in streptococcal molecular genetics and refinement of in vitro and in vivo model systems of GBS disease have led to the discovery and characterization of several extracellular virulence factors elaborated by this pathogen. This review summarizes our current understanding of GBS extracellular virulence factors including the beta-hemolysin/cytolysin, C5a-peptidase, hyaluronate lyase, CAMP factor, oligopeptidase, and carbohydrate exotoxin CM101. The molecular basis and potential pathogenic role(s) of each factor are considered in the context of neonatal infection.
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ISSN:1093-9946
1093-4715
DOI:10.2741/1296