Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats
The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and...
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Published in | Behavioural brain research Vol. 37; no. 2; p. 145 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
05.03.1990
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Subjects | |
Online Access | Get more information |
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Summary: | The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant. |
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ISSN: | 0166-4328 |
DOI: | 10.1016/0166-4328(90)90089-W |