The 34 kilodalton insulin-like growth factor binding proteins in human cerebrospinal fluid and the A673 rhabdomyosarcoma cell line are human homologues of the rat BRL-3A binding protein

Three members of a family of insulin-like growth factor binding proteins have been identified by nucleotide sequencing of cDNA clones: the binding subunit of the 150 kDa IGF-binding protein complex in human serum, the 30 kDa IGF binding protein in human amniotic fluid, and a 30 kDa binding protein (...

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Published inBiochemical and biophysical research communications Vol. 163; no. 2; pp. 875 - 881
Main Authors Romanus, Joyce A., Tseng, Lucy Y.-H., Yang, Yvonne W.-H., Rechler, Matthew M.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 15.09.1989
Elsevier
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Summary:Three members of a family of insulin-like growth factor binding proteins have been identified by nucleotide sequencing of cDNA clones: the binding subunit of the 150 kDa IGF-binding protein complex in human serum, the 30 kDa IGF binding protein in human amniotic fluid, and a 30 kDa binding protein (BP-3A) isolated from the rat BRL-3A cell line. The present study demonstrates by molecular hybridization and immunoreactivity that the human counterpart of rat BP-3A is a 34 kDa IGF binding protein that is present in human cerebrospinal fluid and is synthesized and secreted by the A673 human rhabdomyosarcoma cell line.
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(89)92303-6