Adaptive response in irradiated human lymphocytes: radiobiological and genetical aspects

The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy of X-rays in G0, G1 and S phase as well as with tritiated water (4 muCi/ml) when the 'challenge' dose was given in G2. There wa...

Full description

Saved in:
Bibliographic Details
Published inMutation research Vol. 251; no. 2; p. 181
Main Authors Khandogina, E K, Mutovin, G R, Zvereva, S V, Antipov, A V, Zverev, D O, Akifyev, A P
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.1991
Subjects
Adaptation, Physiological
Adult
Cell Cycle
Cells, Cultured
Down Syndrome - blood
Female
Humans
Infant
Lymphocytes - metabolism
Lymphocytes - radiation effects
Male
Radiation Tolerance
Online AccessGet more information

Cover

More Information
Summary:The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy of X-rays in G0, G1 and S phase as well as with tritiated water (4 muCi/ml) when the 'challenge' dose was given in G2. There was no AR after prior exposure of the cells in S phase to secondary irradiation from 70 GeV protons. The AR was not observed after preliminary X-irradiation of the lymphocytes in G0 and G1 and 'challenge' irradiation in G1. Cells from 6 patients with Down's syndrome were tested. At least 5 of them did not show the AR. The AR is considered to be a phenomenon of the antimutagenic aftereffect.
ISSN:0027-5107
DOI:10.1016/0027-5107(91)90073-W