Translocation 1;7 in four cases of myeloid disorders

A der(1)t(1;7)(p11;p11) was observed in bone marrow chromosome analyses of four patients with myeloproliferative disorders. Three patients had developed secondary leukemias or preleukemias following chemotherapeutic exposure, and one patient was diagnosed with M4 de novo.

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Bibliographic Details
Published inCancer genetics and cytogenetics Vol. 38; no. 1; pp. 49 - 52
Main Authors Sheppard, David M., Richkind, Kathleen E., Bull, Murlin
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.03.1989
Elsevier Science
Subjects
Adult
Aged
Biological and medical sciences
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 7
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Myeloproliferative Disorders - genetics
Translocation, Genetic
Chromosomal aberration
Refractory anemia
Human
Iatrogenic
Premalignant lesion
Hemopathy
Abnormal «C7» chromosome
Syndrome
Abnormal A1 chromosome
Myeloproliferative syndrome
Second cancer
Cytogenetics
Abnormal chromosome
Complication
Acute myelocytic leukemia
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Summary:A der(1)t(1;7)(p11;p11) was observed in bone marrow chromosome analyses of four patients with myeloproliferative disorders. Three patients had developed secondary leukemias or preleukemias following chemotherapeutic exposure, and one patient was diagnosed with M4 de novo.
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ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(89)90164-7