Two further cases of acute myeloid leukemia with trisomy 4

Two cases of acute myeloid leukemia (FAB M1 and M2) with trisomy 4 are described. Morphologic abnormalities were confined to the granulocytic monocytic lineage with no evidence of erythroid or megakaryocytic involvement. One of the cases, who also had trisomy 13, presented initially with skin infilt...

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Published inCancer genetics and cytogenetics Vol. 34; no. 1; pp. 29 - 32
Main Authors Hoyle, Christine F., Boughton, B.J., Hayhoe, F.G.J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.08.1988
Elsevier Science
Subjects
Aged
Biological and medical sciences
Cells, Cultured
Chromosome Banding
Chromosomes, Human, Pair 4
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Pleural Effusion - pathology
Trisomy
Chromosomal aberration
Trisomy
Abnormal B4 chromosome
Cytogenetics
Abnormal chromosome
Aneuploidy
Hemopathy
Acute myelocytic leukemia
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Summary:Two cases of acute myeloid leukemia (FAB M1 and M2) with trisomy 4 are described. Morphologic abnormalities were confined to the granulocytic monocytic lineage with no evidence of erythroid or megakaryocytic involvement. One of the cases, who also had trisomy 13, presented initially with skin infiltration without bone marrow involvement.
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ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(88)90164-1