Effect of serotonergic agents on regional concentrations of somatostatin- and neuropeptide Y-like immunoreactivities in rat brain

A possible role for neuropeptides in affective disorders is suggested by many investigators. Somatostatin-like immunoreactivity (SS-LI) and neuropeptide Y-like immunoreactivity (NPY-LI) concentrations are demonstrated to be reduced in cerebrospinal fluid from depressed patients. We have shown that l...

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Bibliographic Details
Published inBrain research Vol. 599; no. 1; p. 45
Main Authors Kakigi, T, Maeda, K
Format Journal Article
LanguageEnglish
Published Netherlands 18.12.1992
Subjects
5,7-Dihydroxytryptamine - administration & dosage
5,7-Dihydroxytryptamine - pharmacology
Animals
Brain - drug effects
Brain - metabolism
Cerebral Ventricles - drug effects
Cerebral Ventricles - physiology
Desipramine - pharmacology
Drug Administration Schedule
Fenclonine - administration & dosage
Fenclonine - pharmacology
Injections, Intraperitoneal
Injections, Intraventricular
Male
Neuropeptide Y - analysis
Neuropeptide Y - metabolism
Organ Specificity
Radioimmunoassay
Rats
Rats, Wistar
Serotonin - administration & dosage
Serotonin - pharmacology
Somatostatin - analysis
Somatostatin - metabolism
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Summary:A possible role for neuropeptides in affective disorders is suggested by many investigators. Somatostatin-like immunoreactivity (SS-LI) and neuropeptide Y-like immunoreactivity (NPY-LI) concentrations are demonstrated to be reduced in cerebrospinal fluid from depressed patients. We have shown that long-term treatment with serotonin uptake inhibitors, clomipramine and zimelidine, reduce brain SS-LI concentrations in the rat. We have studied the effect of serotonergic agents on regional brain SS-LI and NPY-LI concentrations in rats. Long-term treatment with 5-hydroxytryptamine (5-HTP), a serotonin precursor, caused reductions in SS- and NPY-LI levels in the hypothalamus. SS- and NPY-LI concentrations in the brain were markedly elevated by treatment with p-chlorophenylalanine, a serotonin synthesis inhibitor. Intracerebroventricular administration of 5,7-dihydroxytryptamine, a serotonin neurotoxin, resulted in elevations of both peptides in the brain. These results suggest a inhibitory role for the serotonergic system in the brain in the regulation of SS and NPY.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(92)90850-9