Hexose transport in hybrids between malignant and normal cells

The kinetic parameters of hexose uptake were measured in matched pairs of hybrids between malignant and normal cells. Each pair consisted of a hybrid in which malignancy was initially suppressed and a segregant tumour derived from it. Comparisons were also made between tumour cells and non-tumorigen...

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Bibliographic Details
Published inNature (London) Vol. 294; no. 5838; p. 232
Main Authors White, M K, Bramwell, M E, Harris, H
Format Journal Article
LanguageEnglish
Published England 19.11.1981
Subjects
Animals
Biological Transport, Active
Deoxy Sugars - metabolism
Deoxyglucose - metabolism
Fibroblasts - metabolism
Fibrosarcoma - metabolism
Hexoses - metabolism
Hybridomas - metabolism
Kinetics
Lymphocytes - metabolism
Melanoma - metabolism
Mice
Mice, Inbred C57BL
Neoplasms, Experimental - metabolism
Osteosarcoma - metabolism
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Summary:The kinetic parameters of hexose uptake were measured in matched pairs of hybrids between malignant and normal cells. Each pair consisted of a hybrid in which malignancy was initially suppressed and a segregant tumour derived from it. Comparisons were also made between tumour cells and non-tumorigenic derivatives selected from the tumour cell populations in vitro. Without exception, malignancy, as defined by the ability of the cell to grow progressively in vivo, was found to be linked to a systematic decrease in the Michaelis constant of the hexose transport system.
ISSN:0028-0836
DOI:10.1038/294232a0