Time course of physostigmine effects on neuroendocrine responding at varying environmental temperatures

1. Hypothermia was found to be related to both the dose of physostigmine and the environmental temperature. 2. Plasma corticosterone levels were elevated above controls regardless of dose of physostigmine or environmental temperature. 3. Plasma free fatty acid levels appeared to be inversely related...

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Bibliographic Details
Published inProgress in neuro-psychopharmacology & biological psychiatry Vol. 12; no. 6; p. 935
Main Authors Maickel, R P, Kinney, D R, Ryker, D, Nichols, M B
Format Journal Article
LanguageEnglish
Published England 1988
Subjects
Acclimatization - drug effects
Acetylcholinesterase - metabolism
Animals
Blood Glucose - metabolism
Body Temperature - drug effects
Brain - drug effects
Brain - enzymology
Corticosterone - blood
Erythrocytes - enzymology
Fatty Acids, Nonesterified - blood
Male
Physostigmine - pharmacology
Rats
Rats, Inbred Strains
Reference Values
Temperature
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Summary:1. Hypothermia was found to be related to both the dose of physostigmine and the environmental temperature. 2. Plasma corticosterone levels were elevated above controls regardless of dose of physostigmine or environmental temperature. 3. Plasma free fatty acid levels appeared to be inversely related to physostigmine-induced hypothermia. 4. A hyperglycemic response was observed under all experimental conditions at 0.5 hours and 1.0 hour post injection. 5. Significant inhibition of brain acetylcholinesterase was observed, whereas, plasma and erythrocyte acetylcholinesterase activity was inconsistent.
ISSN:0278-5846
DOI:10.1016/0278-5846(88)90090-5