Increased plasma and aortic triglycerides in rabbits after acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Administration of a single nonlethal dose (20 micrograms/kg) of 2,3,7,8-tetrachlorodibenzo-p-dioxin to New Zealand male rabbits, both on a standard and on a cholesterol (0.5% in the diet) regimen, resulted in a significant increase of plasma triglyceride levels. Triglycerides were particularly raise...

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Published inToxicology and applied pharmacology Vol. 75; no. 1; p. 91
Main Authors Lovati, M R, Galbussera, M, Franceschini, G, Weber, G, Resi, L, Tanganelli, P, Sirtori, C R
Format Journal Article
LanguageEnglish
Published United States 01.08.1984
Subjects
Animals
Aorta - drug effects
Aorta - metabolism
Arteriosclerosis - chemically induced
Cholesterol, Dietary - metabolism
Dioxins - toxicity
Liver - drug effects
Liver - metabolism
Male
Polychlorinated Dibenzodioxins - toxicity
Rabbits
Triglycerides - blood
Triglycerides - metabolism
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Summary:Administration of a single nonlethal dose (20 micrograms/kg) of 2,3,7,8-tetrachlorodibenzo-p-dioxin to New Zealand male rabbits, both on a standard and on a cholesterol (0.5% in the diet) regimen, resulted in a significant increase of plasma triglyceride levels. Triglycerides were particularly raised in the very low-density lipoprotein fraction; no significant apolipoprotein changes, as assessed by an analytical isoelectrofocusing procedure, could be determined. Concomitant to the increased triglyceridemia, aortic triglycerides were also significantly elevated in 2,3,7,8-tetrachlorodibenzo-p-dioxin-pretreated rabbits, both on the standard and on the cholesterolemic regimen. These findings suggest that 2,3,7,8-tetrachlorodibenzo-p-dioxin, possibly by inhibiting triglyceride breakdown, may induce an atherogenic form of hypertriglyceridemia in a standard experimental model of atherosclerosis.
ISSN:0041-008X
DOI:10.1016/0041-008X(84)90079-6