Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells
Highlights • PC-3 prostate cancer cells treated with zoledronate were shown to be resistant to Vγ9Vδ2 T cell cytotoxicity. • Resistance was attributed to the low activity of the mevalonate pathway in these cells. • PC-3 cells could be rendered susceptible to Vγ9Vδ2 T cell mediated cytotoxicity by ac...
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Published in | Cancer letters Vol. 357; no. 1; pp. 279 - 285 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
01.02.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • PC-3 prostate cancer cells treated with zoledronate were shown to be resistant to Vγ9Vδ2 T cell cytotoxicity. • Resistance was attributed to the low activity of the mevalonate pathway in these cells. • PC-3 cells could be rendered susceptible to Vγ9Vδ2 T cell mediated cytotoxicity by activating the mevalonate pathway. • Cholesterol depletion together with ZOL treatment led to high accumulation of IPP, which was recognized by Vγ9Vδ2 T cells. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2014.11.030 |