Eccrine poromatosis associated with polychemotherapy

• Published in: Acta dermato-venereologica Vol. 92; no. 6; pp. 687 - 690
• Main Authors: Fujii, Kazuyasu, Aochi, Seiko, Takeshima, Chinatsu, Ohtsuka, Masaki, Hamada, Toshihisa, Asagoe, Kenji, Aoyama, Yumi, Morizane, Shin, Iwatsuki, Keiji
• Format: Journal Article
• Language: English
• Published: Sweden 01.01.2012
• Subjects: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Biopsy; Dermoscopy; Female; Histiocytoma, Malignant Fibrous - drug therapy; Humans; Lymphoma, Non-Hodgkin - drug therapy; Male; Middle Aged; Poroma - chemically induced; Poroma - pathology; Sweat Gland Neoplasms - chemically induced; Sweat Gland Neoplasms - pathology; Time Factors
• ISSN: 0001-5555; 1651-2057
• DOI: 10.2340/00015555-1279

Eccrine poroma frequently occurs as a solitary tumour, and only a few reports have described the occurrence of multiple lesions. Multiple eccrine poromas, or eccrine poromatosis, may occur in patients who have undergone radiotherapy and/or polychemotherapy. We report here four cases of multiple eccrine poromas in patients who were either undergoing, or had undergone, intensive chemotherapy (from 6 months to 16 years prior to onset). Three patients had non-Hodgkin's lymphoma and one had malignant fibrous histiocytosis. The number of lesions varied from 3 to > 20 in each patient, and all the lesions occurred on non-irradiated skin. The histopathological features were consistent with those of eccrine poroma, Pinkus type. In addition to radiation therapy, intensive chemotherapy may play a role in the pathogenesis of multiple eccrine poromas even many years after treatment.