HHV-6 inhibition by two polar compounds

Dimethyl sulphoxide and dimethyl formamide, two polar compounds and powerful cell differentiation inducers, inhibit HHV-6 infection when added to HHV-6-infected HSB2 cultures. This was established by a delay in the time-course of infection and in the development of virus-induced cytopathic effects....

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Bibliographic Details
Published inAntiviral research Vol. 18; no. 1; p. 27
Main Authors Viza, D, Aranda-Anzaldo, A, Ablashi, D, Kramarsky, B
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.1992
Subjects
Antiviral Agents - pharmacology
Capsid - ultrastructure
Cell Line
Cell Nucleus - microbiology
Cell Nucleus - ultrastructure
Cell Survival - drug effects
Cytopathogenic Effect, Viral
Cytoplasm - microbiology
Cytoplasm - ultrastructure
Dimethyl Sulfoxide - pharmacology
Dimethylformamide - pharmacology
Herpesvirus 6, Human - drug effects
Herpesvirus 6, Human - growth & development
Herpesvirus 6, Human - ultrastructure
Humans
Microscopy, Electron
Virus Replication - drug effects
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Summary:Dimethyl sulphoxide and dimethyl formamide, two polar compounds and powerful cell differentiation inducers, inhibit HHV-6 infection when added to HHV-6-infected HSB2 cultures. This was established by a delay in the time-course of infection and in the development of virus-induced cytopathic effects. Furthermore, viral titration of supernatants showed a significant reduction (3 log10) of the number of infectious particles. Electron microscopy confirmed that viable cells and extracellular virions were present in the cultures containing the polar compounds, while in the non-treated cultures all cells were lysed and no extracellular virus was evident. The mode of action of these compounds is still unclear and warrants further investigation.
ISSN:0166-3542
DOI:10.1016/0166-3542(92)90003-N