Synthesis of okadaic acid-tautomycin hybrid

One of the three spiro-segments in the synthesis of okadaic acid was synthesized under a new heteroconjugate addition strategy. Successive coupling of this spiro-segment with two tautomycin- synthetic segments afforded a hybrid molecule between okadaic acid and tautomycin.

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Bibliographic Details
Published inSynlett no. 6; pp. 713 - 715
Main Authors Tsuboi, K, Ichikawa, Y, Isobe, M
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.06.1997
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PROTEIN
NATURAL-PRODUCTS
C segment of OKA
EFFICIENT MACROLACTONIZATION
okadaic acid
tautomycin
SILYLACETYLENES
hybrid molecule
AB segment of TTM
CALYCULIN-A
MARINE POLYETHER TOXIN
SEGMENT-C
CHIRAL SYNTHESIS
PHOSPHATASE-1
protein phosphatase inhibitor
HETEROCONJUGATE ADDITION
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Summary:One of the three spiro-segments in the synthesis of okadaic acid was synthesized under a new heteroconjugate addition strategy. Successive coupling of this spiro-segment with two tautomycin- synthetic segments afforded a hybrid molecule between okadaic acid and tautomycin.
ISSN:0936-5214
DOI:10.1055/s-1997-3257