Scaling-up medical technologies using flexographic printing

• Published in: Talanta (Oxford) Vol. 219; p. 121236
• Main Authors: Assaifan, Abdulaziz K., Al habis, Nuha, Ahmad, Iftikhar, Alshehri, Naif Ahmed, Alharbi, Hamad F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020
• Subjects: Biosensors; Biotechnology; Equipment and Supplies; Flexographic printing; Point-of-care; Printing, Three-Dimensional; Biotechnology; Point-of-care; Biosensors; Flexographic printing
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2020.121236

Medical technologies, such as point-of-care devices and biological and chemical assays which rely on functional materials deposited on top of substrates, are in great demand due to an increase in the prevalence of diseases worldwide. A significant number of these medical technologies are still in their infancy with respect to commercialization because of the high cost, material and complexity of the conventionally available fabrication techniques. As a result, medical technologies, in broad terms, require low cost and mass production fabrication methods in order to overcome the commercialization challenges. Recently, researchers have explored the flexographic printing technique which is widely employed for food packaging and newspaper production. This technique has proved cost-effective, facile, rapid and industrially compatible fabrication technique of functional materials for various applications. In this review, we provide an account of the attempts of flexographic printing made to scale up functional materials on surfaces for biomedical applications. Firstly, we offer justification for demanding high-throughput fabrication techniques. We then present the facile working principle of the flexographic printing and its use in different medical applications, for example chronic disease monitoring devices, colorimetric sensors, electrochemical sensors, assays and drugs. Finally, we discuss challenges of the fabrication technique. The main purpose of this review is to give insights into the usefulness of flexographic printing to the health care industry. [Display omitted] •Facile production of functional materials for healthcare applications is feasible using flexographic printing.•The basic working mechanism of flexographic printing is described.•Contributions of flexographic printing in fabricating medical technologies are reviewed.•Technical challenges of the printing technique are summarized.