Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects

• Published in: Genetics and molecular research Vol. 13; no. 3; pp. 5143 - 5153
• Main Authors: Miao, D.M., Zhang, L.P., Yu, H.P., Zhang, J.Y., Xiao, W.K., Ye, P.
• Format: Journal Article
• Language: English
• Published: Brazil 07.07.2014
• Subjects: Age Factors; Aged; Biomarkers - blood; Blood Glucose - metabolism; Blood Pressure; Cardiomegaly - blood; Cardiomegaly - complications; Cardiomegaly - diagnosis; Cardiomegaly - physiopathology; Case-Control Studies; Fasting; Humans; Hypertension - blood; Hypertension - complications; Hypertension - diagnosis; Hypertension - physiopathology; Male; Middle Aged; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Prognosis; Sex Factors; Troponin T - blood; Ventricular Remodeling
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2014.July.7.7

It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT levels are related to left ventricular (LV) remodeling and performance in hypertension. We included 537 hemodynamically stable hypertensive subjects, 247 males aged 60.7 ± 11.1 years, and 100 normotensive subjects of similar age and gender. Clinical examination, clinical assessment and laboratory assays were performed for all hypertensive and normotensive subjects. The detectable rate (>0.003 ng/mL) and elevated rate (>0.013 ng/mL) of hs-TnT were higher in hypertensive subjects than those in normotensive subjects. hs-TnT level gradually increased in hypertensive subjects with LV normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. hs-TnT was independently related to age, gender, hypertension, fasting blood glucose, renal function, and LV hypertrophy, and diastolic function on multiple analysis during the whole participation. An increase in hs-TnT levels could be a reliable biomarker of cardiac remodeling and function in hypertension, as an indicator of subclinical ongoing cardiomyocyte injury.