Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats

Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperac...

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Bibliographic Details
Published inBrain research Vol. 435; no. 1-2; p. 371
Main Authors O'Neill, K A, Liebman, J M
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.1987
Subjects
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - antagonists & inhibitors
Aspartic Acid - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Cerebral Ventricles - drug effects
Cerebral Ventricles - physiology
Injections, Intraventricular
Kinetics
Male
Motor Activity - drug effects
N-Methylaspartate
Piperazines - administration & dosage
Piperazines - pharmacology
Rats
Rats, Inbred Strains
Time Factors
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Summary:Injection of the specific N-methyl-D-aspartate (NMDA) antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), into the frontal cortex of rats, induced hyperactivity characterized by unique episodic darting behavior. This behavioral profile contrasts sharply with the ataxia and hyperactivity seen after intracerebroventricular CPP and other NMDA antagonists.
ISSN:0006-8993
DOI:10.1016/0006-8993(87)91628-3