Frequency-dependent neuromuscular blockade by textilotoxin in vivo

The effect of stimulation frequency on the timecourse of neuromuscular blockade, following the administration of textilotoxin (20 micrograms/kg) or beta-bungarotoxin (50 micrograms/kg), was examined in the interdigital muscles of the hindlimb in anaesthetized mice. While the time of death was variab...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 29; no. 10; p. 1266
Main Authors Lloyd, D R, Nicholson, G M, Spence, I, Connor, M, Tyler, M I, Howden, M E
Format Journal Article
LanguageEnglish
Published England 1991
Subjects
Action Potentials - drug effects
Animals
Bungarotoxins - pharmacology
Diaphragm - drug effects
Diaphragm - innervation
Elapid Venoms - pharmacology
Electrocardiography - drug effects
Heart Rate - drug effects
Male
Mice
Neuromuscular Blocking Agents - pharmacology
Neuromuscular Junction - drug effects
Phrenic Nerve - drug effects
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Summary:The effect of stimulation frequency on the timecourse of neuromuscular blockade, following the administration of textilotoxin (20 micrograms/kg) or beta-bungarotoxin (50 micrograms/kg), was examined in the interdigital muscles of the hindlimb in anaesthetized mice. While the time of death was variable, neuromuscular blockade of the interdigital muscles occurred at the same time as respiratory failure with both textilotoxin and beta-bungarotoxin only at stimulation rates of 0.5 Hz and above. Textilotoxin (50 micrograms/kg) produced an increase in the heart rate prior to death but no change in the shape of the electrocardiogram.
ISSN:0041-0101
DOI:10.1016/0041-0101(91)90199-2