Appraisal of rabies vaccine potency by determination of in vitro, specific interleukin-2 production

The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 +CD8 − lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from...

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Published inBiologicals Vol. 19; no. 2; pp. 113 - 123
Main Authors Joffret, Marie-Line, Zanetti, Carlos, Morgeaux, Sylvie, Leclerc, Claude, Sureau, Pierre, Perrin, Pierre
Format Journal Article
LanguageEnglish
Published Kent Elsevier Ltd 01.04.1991
Elsevier Science
Subjects
Animals
Antibodies, Viral - biosynthesis
Bacteriology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Interleukin-2 - biosynthesis
Lymphocytes - immunology
Mice
Mice, Inbred Strains
Microbiology
Neutralization Tests
Rabies - prevention & control
Rabies Vaccines - pharmacology
Rabies Vaccines - standards
rabies virus
Rats
Species Specificity
Vaccines, Inactivated - pharmacology
Vaccines, Inactivated - standards
Infection
Vertebrata
Mammalia
Mouse
Secretion
Viral disease
Interleukin
Rabies
Rodentia
Vaccine
Quantitative analysis
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Abstract The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 +CD8 − lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from different rabies and rabies-related strains. IL-2 production was specilic, reproducible and correlated with the vaccine protective activity as determined by the pre-exposure NIH test. Our results suggest that measurement of IL-2 production could be used for the appraisal of rabies vaccine potency.
AbstractList The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 +CD8 − lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from different rabies and rabies-related strains. IL-2 production was specilic, reproducible and correlated with the vaccine protective activity as determined by the pre-exposure NIH test. Our results suggest that measurement of IL-2 production could be used for the appraisal of rabies vaccine potency.
The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 super(+)CD8 super(-) lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from different rabies and rabies-related strains. IL-2 production was specific, reproducible and correlated with the vaccine protective activity as determined by the pre-exposure NIH test. Our results suggest that measurement of IL-2 production could be used for the appraisal of rabies vaccine potency.
The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4+CD8- lymphocytes. IL-2 production by splenocytes from mice immunized with various vaccines was measured following in vitro stimulation with antigens from different rabies and rabies-related strains. IL-2 production was specific, reproducible and correlated with the vaccine protective activity as determined by the pre-exposure NIH test. Our results suggest that measurement of IL-2 production could be used for the appraisal of rabies vaccine potency.
Author Leclerc, Claude
Morgeaux, Sylvie
Joffret, Marie-Line
Perrin, Pierre
Zanetti, Carlos
Sureau, Pierre
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Issue 2
Keywords Infection
Vertebrata
Mammalia
Mouse
Secretion
Viral disease
Interleukin
Rabies
Rodentia
Vaccine
Quantitative analysis
Language English
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Snippet The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 +CD8 −...
The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4+CD8-...
The potency of different rabies vaccines was measured via cell mediated immunity (CMI) assessed by the production of interleukin-2 (IL-2) by CD4 super(+)CD8...
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StartPage 113
SubjectTerms Animals
Antibodies, Viral - biosynthesis
Bacteriology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Interleukin-2 - biosynthesis
Lymphocytes - immunology
Mice
Mice, Inbred Strains
Microbiology
Neutralization Tests
Rabies - prevention & control
Rabies Vaccines - pharmacology
Rabies Vaccines - standards
rabies virus
Rats
Species Specificity
Vaccines, Inactivated - pharmacology
Vaccines, Inactivated - standards
Title Appraisal of rabies vaccine potency by determination of in vitro, specific interleukin-2 production
URI https://dx.doi.org/10.1016/1045-1056(91)90009-9
https://www.ncbi.nlm.nih.gov/pubmed/1888490
https://search.proquest.com/docview/16678488
https://search.proquest.com/docview/72083176
Volume 19
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