Effects of haemagglutination (lectin) inhibitory sugars on Theileria parva infection in Rhipicephalus appendiculatus

• Published in: International journal for parasitology Vol. 25; no. 1; pp. 29 - 35
• Main Authors: Kamwendo, S.P., Musisi, F.L., Trees, A.J., Molyneux, D.H.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1995; Elsevier Science
• Subjects: Acari; Animals; Biological and medical sciences; Carbohydrates - pharmacology; Cattle; Disaccharides - pharmacology; Female; Fundamental and applied biological sciences. Psychology; haemagglutination; Hemagglutination - drug effects; inhibitory sugars; Ixodidae; Male; Mannose - pharmacology; Medically important nuisances and vectors, pests of stored products and materials: population survey and control; Melibiose - pharmacology; Rabbits; Raffinose - pharmacology; Rhipicephalus appendiculatus; Salivary Glands - parasitology; Theileria parva; Theileria parva - drug effects; Theileria parva - growth & development; Theileria parva - pathogenicity; Theileriasis - etiology; Theileriasis - parasitology; Ticks - parasitology; Vectors. Intermediate hosts; haemagglutination; Theileria parva; Rhipicephalus appendiculatus; inhibitory sugars; Parasitiformes; Protozoa; Host parasite relation; Parasite; Host; Mannose; Raffinose; Arachnida; Hemagglutination; Acari; Ixodida; Melibiose; Arthropoda; Livestock; Inhibitor; Invertebrata; Sporozoa; Vector; Ixodidae
• ISSN: 0020-7519; 1879-0135
• DOI: 10.1016/0020-7519(94)00072-V

We have previously described the presence of haemagglutinins in tissues of the tick, Rhipicephalus appendiculatus and determined their sugar specificities by inhibition experiments. In this study, haemagglutination inhibitory sugars are shown to have an effect in vivo on the abundance of Theileria parva infected salivary gland acini in Rhipicephalus appendiculatus. A significant increase ( P < 0.05) was observed in T. parva acinar infection rates in the salivary glands of R. appendiculatus fed on ears of rabbits infused with melibiose and raffinose. In contrast, mannose and turanose (non-haemagglutination inhibitory sugars) did not cause elevation of T. parva acinar infection rates. The effect of melibiose in elevating acinar infections was observed when used only during T. parva maturation in the salivary glands but not during parasite pick-up from an infected bovine host. Stabilates produced from ticks with elevated acinar infections did not differ from control stabilates in infectivity to cattle, by comparison of prepatent periods to pyrexia, or parasitosis, or in the severity of reactions.