The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia

• Published in: European journal of pharmacology Vol. 282; no. 1; pp. 259 - 262
• Main Authors: Maginn, Mark, Caldwell, Maeve, Kelly, J.P., Leonard, B.E.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25.08.1995; Elsevier
• Subjects: Alanine - analogs & derivatives; Alanine - pharmacology; Animals; AP-3 (2-amino-3-phosphonopropionate); Biological and medical sciences; Brain Ischemia - drug therapy; Gerbillinae; Ischemia; Male; Medical sciences; Metabotropic glutamate receptor; Motor Activity - drug effects; Nerve Degeneration - physiology; Neurons - physiology; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Ischemia; AP-3 (2-amino-3-phosphonopropionate); Metabotropic glutamate receptor; Nervous system diseases; Rodentia; Cardiovascular disease; Neuroprotective agent; Glutamate receptor; Cerebral disorder; Vascular disease; Prevention; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Animal; Central nervous system disease; Antagonist; Gerbil; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(95)00400-F

The effect of 2-amino-3-phosphonopropionate (AP-3), a metabotropic glutamate receptor antagonist on behavioural and histological changes following global ischaemia was investigated on the Mongolian gerbil. Ischaemia was induced by bilateral carotid occlusion for 5 min. AP-3 was administered i.p. (25 or 250 mg/kg) 30 min before and 24 h after surgery. Significant neuroprotection was observed 96 h after surgery to cells in the CA1 region of the hippocampus in drug treated animals. AP-3 (250 mg/kg) significantly attenuated the increase in locomotor activity measured 72 h after surgery. These results suggest that metabotropic glutamate receptors play a role in the neurodegeneration seen following ischaemia.