Antiplasmodial and anticancer activities of xanthones isolated from Garcinia bancana Miq

• Published in: Natural product research Vol. 38; no. 5; pp. 885 - 890
• Main Authors: Rifaldi, Fadlan, Arif, Fatmawati, Sri, Purnomo, Adi Setyo, Ersam, Taslim
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01.02.2024
• Subjects: Anticancer properties; Antiprotozoal agents; Antitumor activity; Chloroquine; Garcinia; Hydrogen bonding; L-Lactate dehydrogenase; Lactate dehydrogenase; Molecular docking; Natural resources; Tumor cell lines; Clusiaceae; molecular docking; Garcinia bancana Miq; anticancer; antiplasmodial; xanthone
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2023.2199212

This report describes the isolation and characterization of xanthones from Miq. and evaluates their antiplasmodial and anticancer activities. Macluraxanthone ( ), isojacareubin ( ), and gerontoxanthone C ( ) were isolated from the stem bark of Miq. for the first time. molecular docking studies revealed the hydrogen bonding and steric interactions between xanthones ( - ) and LDH/VEGFR2. The antiplasmodial activity was assayed against the chloroquine-sensitive strain 3D7 by the lactate dehydrogenase (LDH) method. The anticancer evaluation was evaluated against the A549, MCF-7, HeLa, and B-16 cancer cell lines. Compounds ( ) (IC 8.45-16.71 μM) and ( ) (IC 9.69-14.86 μM) showed more potent anticancer activity than compound ( ) (IC 25.46-31.31 μM), as well for their antiplasmodial activity (4.28 μM, 5.52 μM, 11.45 μM). Our findings indicated the potential of Miq. as a natural resource of antiplasmodial and anticancer compounds.