Transcutaneous spinal cord stimulation of the cervical cord modulates lumbar networks

• Published in: Journal of neurophysiology Vol. 123; no. 1; pp. 158 - 166
• Main Authors: Barss, Trevor S, Parhizi, Behdad, Mushahwar, Vivian K
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020
• Subjects: Adult; Cervical Cord - physiology; Electromyography; Female; H-Reflex - physiology; Humans; Lumbar Vertebrae; Male; Motor Activity - physiology; Muscle, Skeletal; Nerve Net - physiology; Spinal Cord - physiology; Spinal Cord Injuries - rehabilitation; Spinal Cord Stimulation; spinal cord injury; rehabilitation; interlimb; locomotion; cycling; transcutaneous spinal cord stimulation; electromyography, H-reflex
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00433.2019

It has been established that coordinated arm and leg (A&L) cycling facilitates corticospinal drive and modulation of cervico-lumbar connectivity and ultimately improves overground walking in people with incomplete spinal cord injury or stroke. This study examined the effect of noninvasive transcutaneous spinal cord stimulation (tSCS) on the modulation of cervico-lumbar connectivity. Thirteen neurologically intact adults participated in the study. The excitability of the Hoffmann (H) reflex elicited in the soleus muscle was examined under multiple conditions involving either the arms held in a static position or rhythmic arm cycling while tSCS was applied to either the cervical or lumbar cord. As expected, soleus H-reflex amplitude was significantly suppressed by 19.2% during arm cycling (without tSCS) relative to arms static (without tSCS). Interestingly, tSCS of the cervical cord with arms static significantly suppressed the soleus H-reflex (-22.9%), whereas tSCS over the lumbar cord did not suppress the soleus H-reflex (-3.8%). The combination of arm cycling with cervical or lumbar tSCS did not yield additional suppression of the soleus H-reflex beyond that obtained with arm cycling alone or cervical tSCS alone. The results demonstrate that activation of the cervical spinal cord through both rhythmic arm cycling and tonic tSCS significantly modulates the activity of lumbar networks. This highlights the potential for engaging cervical spinal cord networks through tSCS during rehabilitation interventions to enhance cervico-lumbar connectivity. This connectivity is influential in facilitating improvements in walking function after neurological impairment. This is the first study to investigate the modulatory effects of transcutaneous spinal cord stimulation (tSCS) on cervico-lumbar connectivity. We report that both rhythmic activation of the cervical spinal cord through arm cycling and tonic activation of the cervical cord through tSCS significantly modulate the activity of lumbar networks. This suggests that engaging cervical spinal cord networks through tSCS during locomotor retraining interventions may not only enhance cervico-lumbar connectivity but also further improve walking capacity.