Effects of AIT-082, a Purine Derivative, on Tremor Induced by Arecoline or Oxotremorine in Mice

The effects of AIT-082, a hypoxanthine derivative, on tremor in mice were investigated. The mice received intragastric administration of AIT-082 for consecutive 60 days at doses of 150, 300 and 600 mg·kg –1 . The results showed that AIT-082 not only effectively inhibited the tremor induced by arecol...

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Bibliographic Details
Published inPharmacology Vol. 80; no. 1; pp. 21 - 26
Main Authors Nannan, Gao, Runmei, Yang, Fusheng, Lin, Shoulan, Zhang, Guangqing, Lei
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2007
Subjects
Aminobenzoates - therapeutic use
Animals
Arecoline - antagonists & inhibitors
Arecoline - toxicity
Dose-Response Relationship, Drug
Hypoxanthines - therapeutic use
Male
Mice
Mice, Inbred ICR
Muscarinic Agonists - toxicity
Original Paper
Oxotremorine - antagonists & inhibitors
Oxotremorine - toxicity
Tremor - chemically induced
Tremor - prevention & control
Tremor
AIT-082
Parkinson's disease
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Summary:The effects of AIT-082, a hypoxanthine derivative, on tremor in mice were investigated. The mice received intragastric administration of AIT-082 for consecutive 60 days at doses of 150, 300 and 600 mg·kg –1 . The results showed that AIT-082 not only effectively inhibited the tremor induced by arecoline or oxotremorine, but also alleviated the tremor intensity and significantly shortened the tremor durations. The inhibition of tremor was perhaps associated with the central cholinergic nerve depressant effects as well as the stimulation of proliferation and differentiation of nerve cells.
ISSN:0031-7012
1423-0313
DOI:10.1159/000102601