The lack of correlation between toxicity and free radical formation of two diaziridinyl benzoquinones

L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones, 2,5-bis(carboethoxyamino)3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ). BZQ sho...

Full description

Saved in:
Bibliographic Details
Published inBiochemical pharmacology Vol. 37; no. 10; p. 2023
Main Authors Lea, J S, Garner, H J, Butler, J, Hoey, B M, Ward, T H
Format Journal Article
LanguageEnglish
Published England 15.05.1988
Subjects
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Aziridines - metabolism
Aziridines - pharmacology
Azirines - pharmacology
Benzoquinones
Cell Survival - drug effects
Free Radicals
Quinones
Superoxides - metabolism
Online AccessGet more information

Cover

More Information
Summary:L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones, 2,5-bis(carboethoxyamino)3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ). BZQ showed a high level of toxicity in both cell lines, but no ESR signal was detectable, while AZQ readily produced an ESR signal but much lower cytotoxicity was observed, particularly in L1210 cells. The rate of superoxide formation was measured for each drug. The results demonstrate that cell killing and free radical production do not necessarily concur.
ISSN:0006-2952
DOI:10.1016/0006-2952(88)90551-5