Effect of cholesterol alpha and beta epoxides on cell killing and transformation

V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5 alpha,6 alpha, and 5 beta,6 beta-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with...

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Bibliographic Details
Published inBiochemical pharmacology Vol. 36; no. 14; p. 2369
Main Authors Raaphorst, G P, Azzam, E I, Langlois, R, Van Lier, J E
Format Journal Article
LanguageEnglish
Published England 15.07.1987
Subjects
Animals
Cell Line
Cell Survival - drug effects
Cell Transformation, Neoplastic - drug effects
Cholesterol - analogs & derivatives
Cholesterol - pharmacology
Cricetinae
Cricetulus
Embryo, Mammalian
Fibroblasts - drug effects
Lung
Male
Mice
Mice, Inbred C3H
Stereoisomerism
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Summary:V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5 alpha,6 alpha, and 5 beta,6 beta-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with epoxide concentration and exposure time. The 5 beta,6 beta-epoxide caused a higher level of transformation than the alpha-isomer, and this is consistent with its greater toxicity.
ISSN:0006-2952
DOI:10.1016/0006-2952(87)90605-8