Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro

Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the re...

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Published inDevelopmental biology Vol. 133; no. 1; pp. 309 - 311
Main Authors Mallat, M., Houlgatte, R., Brachet, P., Prochiantz, A.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.05.1989
Elsevier
Subjects
Animals
Biological and medical sciences
Brain - cytology
Cell Count
Cell Line
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Lipopolysaccharides - pharmacology
Macrophages - metabolism
Molecular embryology
Nerve Growth Factors - metabolism
Peritoneal Cavity - cytology
Rats
Cell culture
Brain
Glial cell
Embryo
Rat
Rodentia
Central nervous system
Nerve growth factor
Lipids
Stimulation
In vitro
Blood
Vertebrata
Mammalia
Development
Lipopolysaccharide
Differentiation
Macrophage
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Summary:Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the regenerative events that follow localized lesions.
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ISSN:0012-1606
1095-564X
DOI:10.1016/0012-1606(89)90322-9