Anticyclic Citrullinated Peptide Antibodies 3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis

We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual is...

Full description

Saved in:
Bibliographic Details
Published inJournal of rheumatology Vol. 46; no. 12; p. 1556
Main Authors Berens, Heather M, Polinski, Kristen J, Mikuls, Ted R, Khatter, Sonia, August, Justin, Visser, Ashley, Mahler, Michael, Weisman, Michael H, O'Dell, James R, Keating, Richard M, Buckner, Jane H, Gregersen, Peter K, Norris, Jill M, Holers, V Michael, Deane, Kevin D, Demoruelle, M Kristen
Format Journal Article
LanguageEnglish
Published Canada 01.12.2019
Subjects
Adult
Age Factors
Aged
Anti-Citrullinated Protein Antibodies - blood
Arthritis, Rheumatoid - blood
Autoantibodies - blood
Female
Humans
Immunoglobulin A - blood
Male
Middle Aged
RHEUMATOID ARTHRITIS
ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES
AGE
Online AccessGet more information

Cover

More Information
Summary:We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.
ISSN:0315-162X
DOI:10.3899/jrheum.180897