Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives

• Published in: Expert reviews in molecular medicine Vol. 24; p. e30
• Main Authors: Huang, Yinqiong, Hu, Keyue, Lin, Shu, Lin, Xiahong
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 05.09.2022
• Subjects: Acids; Apoptosis; Biosynthesis; Body fat; Breast cancer; Cytoplasm; Endoplasmic reticulum; Energy storage; Enzymes; Fatty liver; Genotype & phenotype; Glycerol; Glycerol-3-phosphate; Insulin; Insulin resistance; Isoforms; Liver cancer; Mammals; Medical prognosis; Metabolic syndrome; Mitochondria; Musculoskeletal system; Proteins; Review; Sperm; Spermatogenesis; Steatosis; Transcription factors; metabolic syndrome; triacylglycerol; insulin resistance; Glycerol-3-phosphate acyltransferases; obesity

Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic re...