Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives

Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic re...

Full description

Saved in:
Bibliographic Details
Published inExpert reviews in molecular medicine Vol. 24; p. e30
Main Authors Huang, Yinqiong, Hu, Keyue, Lin, Shu, Lin, Xiahong
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 05.09.2022
Subjects
Acids
Apoptosis
Biosynthesis
Body fat
Breast cancer
Cytoplasm
Endoplasmic reticulum
Energy storage
Enzymes
Fatty liver
Genotype & phenotype
Glycerol
Glycerol-3-phosphate
Insulin
Insulin resistance
Isoforms
Liver cancer
Mammals
Medical prognosis
Metabolic syndrome
Mitochondria
Musculoskeletal system
Proteins
Review
Sperm
Spermatogenesis
Steatosis
Transcription factors
metabolic syndrome
triacylglycerol
insulin resistance
Glycerol-3-phosphate acyltransferases
obesity
Online AccessGet full text

Cover

More Information
Summary:Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1462-3994
1462-3994
DOI:10.1017/erm.2022.23