Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives

Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic re...

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Published inExpert reviews in molecular medicine Vol. 24; p. e30
Main Authors Huang, Yinqiong, Hu, Keyue, Lin, Shu, Lin, Xiahong
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 05.09.2022
Subjects
Acids
Apoptosis
Biosynthesis
Body fat
Breast cancer
Cytoplasm
Endoplasmic reticulum
Energy storage
Enzymes
Fatty liver
Genotype & phenotype
Glycerol
Glycerol-3-phosphate
Insulin
Insulin resistance
Isoforms
Liver cancer
Mammals
Medical prognosis
Metabolic syndrome
Mitochondria
Musculoskeletal system
Proteins
Review
Sperm
Spermatogenesis
Steatosis
Transcription factors
metabolic syndrome
triacylglycerol
insulin resistance
Glycerol-3-phosphate acyltransferases
obesity
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Abstract Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.
AbstractList Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.
Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.
ArticleNumber e30
Author Hu, Keyue
Lin, Xiahong
Lin, Shu
Huang, Yinqiong
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  givenname: Xiahong
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Snippet Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four...
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SubjectTerms Acids
Apoptosis
Biosynthesis
Body fat
Breast cancer
Cytoplasm
Endoplasmic reticulum
Energy storage
Enzymes
Fatty liver
Genotype & phenotype
Glycerol
Glycerol-3-phosphate
Insulin
Insulin resistance
Isoforms
Liver cancer
Mammals
Medical prognosis
Metabolic syndrome
Mitochondria
Musculoskeletal system
Proteins
Review
Sperm
Spermatogenesis
Steatosis
Transcription factors
Title Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives
URI https://www.cambridge.org/core/product/identifier/S1462399422000230/type/journal_article
https://www.proquest.com/docview/2713932177
https://www.proquest.com/docview/2709911192
Volume 24
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