Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

• Published in: Neuron (Cambridge, Mass.) Vol. 53; no. 4; pp. 483 - 486
• Main Authors: Pardossi-Piquard, Raphaëlle, Dunys, Julie, Kawarai, Toshitaka, Sunyach, Claire, Alves da Costa, Cristine, Vincent, Bruno, Sévalle, Jean, Pimplikar, Sanjay, St George-Hyslop, Peter, Checler, Frédéric
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.02.2007; Elsevier
• Subjects: Life Sciences
• ISSN: 0896-6273; 1097-4199
• DOI: 10.1016/j.neuron.2007.01.024

Results and Discussion There is consensus on several important points. Both groups find that NEP expression is dramatically reduced in PS1-/-:PS2-/- double-knockout mouse embryonic fibroblasts (MEFs) (Figures 1D and 1E in Pardossi-Piquard et al., 2005; Figures 1A and 1B in this paper; Figure 1C in Chen and Selkoe, 2007). Both groups find modest reductions (<=25%) in NEP expression in PS1-/-:PS2-/- double-knockout BD8 blastocyst cells (Figures 1F and 1G in Pardossi-Piquard et al., 2005; Figure 1A in Chen and Selkoe, 2007). Both groups observe either modest or no consistent change in NEP expression in single-knockout PS1-/-, PS2-/-, APP-/-, and APLP-2-/- MEFs (Figures 3C and 6C in Pardossi-Piquard et al., 2005; Figures 1A and 1B in this paper; Figures 1C and 4C in Chen and Selkoe, 2007).