NADPH-diaphorase-positive neurons in the auditory cortex of young and old rats

Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young a...

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Bibliographic Details
Published inNeuroreport Vol. 14; no. 3; p. 363
Main Authors Ouda, L, Nwabueze-Ogbo, F C, Druga, R, Syka, J
Format Journal Article
LanguageEnglish
Published England 03.03.2003
Subjects
Aging - metabolism
Animals
Auditory Cortex - cytology
Auditory Cortex - enzymology
Auditory Cortex - pathology
Cell Count
Dendrites - ultrastructure
Male
NADPH Dehydrogenase - metabolism
Neurons - enzymology
Rats
Rats, Long-Evans
Tissue Distribution
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Summary:Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young animals, as well as changes in the shape and configuration of nerve cell bodies and dendrites. Quantitative analysis demonstrated an age-related increase in the number of dendritic segments and dendritic branching points. The length of dendrites in NADPH-d-positive neurons and their density increased in very old rats. The total number of NADPH-d-positive neurons within the Te 1 and Te 3 fields was 13% lower in the old rats than in the young.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-200303030-00013