Investigating trajectories of aging using high-dimensional phenotyping in mice

Despite centuries of effort from philosophers, physicians and biologists, the answer to the seemingly simple question “what is aging?” remains elusive. Some even posit that aging represents a phenomenon too expansive to ever be succinctly defined. A new study tackles this question by profiling hundr...

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Bibliographic Details
Published inLab animal Vol. 52; no. 3; pp. 61 - 62
Main Authors MacArthur, Michael R, Mitchell, Sarah J
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.03.2023
Subjects
Age
Aging
Animals
Cancer
Genotype & phenotype
Intervention
Medical research
Mice
Phenotype
Phenotypes
Phenotyping
Tumorigenesis
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Summary:Despite centuries of effort from philosophers, physicians and biologists, the answer to the seemingly simple question “what is aging?” remains elusive. Some even posit that aging represents a phenomenon too expansive to ever be succinctly defined. A new study tackles this question by profiling hundreds of phenotypes across age in mice and examining how the trajectories of these phenotypes are altered by geroprotective genetic and dietary interventions.
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ISSN:0093-7355
1548-4475
DOI:10.1038/s41684-023-01122-3