The selective Na+-Ca2+exchange inhibitor attenuates brain edema after radiofrequency lesion in rats

• Published in: European journal of pharmacology Vol. 489; no. 3; pp. 193 - 196
• Main Authors: KOYAMA, Yutaka, MATSUI, Shigeo, ITOH, Soichi, OSAKADA, Masakazu, BABA, Akemichi, MATSUDA, Toshio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 12.04.2004
• Subjects: Aniline Compounds - administration & dosage; Aniline Compounds - pharmacokinetics; Aniline Compounds - therapeutic use; Animals; Biological and medical sciences; Brain Chemistry; Brain Edema - etiology; Brain Edema - pathology; Brain Edema - prevention & control; Brain Infarction - etiology; Brain Infarction - pathology; Catheter Ablation - adverse effects; Evans Blue - metabolism; Extravasation of Diagnostic and Therapeutic Materials - metabolism; Extravasation of Diagnostic and Therapeutic Materials - prevention & control; Fluorescein - metabolism; Injections, Intravenous; Male; Medical sciences; Pharmacology. Drug treatments; Phenyl Ethers - administration & dosage; Phenyl Ethers - pharmacokinetics; Phenyl Ethers - therapeutic use; Rats; Rats, Wistar; Serum Albumin - drug effects; Serum Albumin - metabolism; Sodium-Calcium Exchanger - antagonists & inhibitors; Sodium-Calcium Exchanger - metabolism; Sodium-Calcium Exchanger - therapeutic use; Nervous system diseases; Rat; Rodentia; Central nervous system; Brain edema; Blood brain barrier; Cerebral disorder; Radiofrequency lesion; Vertebrata; Mammalia; Na; Sodium; Animal; Central nervous system disease; exchanger; Lesion; Cerebral edema; SEA0400; Ca; Na+ Ca2+ exchanger
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2004.03.018

2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a specific inhibitor of the Na+-Ca2+ exchanger, exerts cytoprotective action and reduces brain infarct volume after cerebral ischemia. We examined the effect of SEA0400 on vasogenic brain edema in rats. Histological observations showed that radiofrequency current caused brain infarct and extravasation of endogenous albumin in the brain. SEA0400 (3 and 10 mg/kg, i.v.) significantly suppressed the increase in brain water content with attenuation of Evans blue dye and sodium fluorescein extravasation after radiofrequency lesion. The findings suggest that the Na+-Ca2+ exchanger plays a role in vasogenic edema formation after radiofrequency lesion.