Brugada Syndrome Associated With Adolescent Loperamide Abuse
We present the case of a 14-year-old boy with obesity, hypertension, and chronic loperamide abuse who presented to our facility with symptoms of opioid withdrawal and type 1 Brugada pattern on an electrocardiogram. He was treated for anxiety and withdrawal. There were no documented dysrhythmias. His...
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| Published in | Pediatrics (Evanston) Vol. 142; no. 4 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.10.2018
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| Online Access | Get more information |
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| Summary: | We present the case of a 14-year-old boy with obesity, hypertension, and chronic loperamide abuse who presented to our facility with symptoms of opioid withdrawal and type 1 Brugada pattern on an electrocardiogram. He was treated for anxiety and withdrawal. There were no documented dysrhythmias. His Brugada pattern resolved by hospital day 5 and remained resolved 12 days postadmission. Genetic testing revealed a heterozygous missense mutation in the SCN5A gene (c. 5038G>A, p. Ala1680Thr), which has been reported in association with Brugada syndrome. To date, there are no published reports of pediatric loperamide use associated with a Brugada pattern on an electrocardiogram. We propose that chronic loperamide use unmasked the electrocardiographic phenotype associated with his gene mutation. |
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| ISSN: | 1098-4275 |
| DOI: | 10.1542/peds.2018-1423 |