Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracell...
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Published in | British journal of pharmacology Vol. 2023; pp. 1 - 24 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Wiley
07.09.2023
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Abstract | Abstract
Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling and downstream cellular responses that are commonly dysregulated in ASD. Despite hundreds of GPCRs being expressed in the brain, only 23 are genetically associated with ASD according to the Simons Foundation Autism Research Initiative (SFARI) gene database: oxytocin OTR; vasopressin V
1A
and V
1B
; metabotropic glutamate mGlu
5
and mGlu
7
; GABA
B2
; dopamine D
1
, D
2
and D
3
; serotoninergic 5‐HT
1B
; β
2
‐adrenoceptor; cholinergic M
3
; adenosine A
2A
and A
3
; angiotensin AT
2
; cannabinoid CB
1
; chemokine CX
3
CR1; orphan GPR37 and GPR85; and olfactory OR1C1, OR2M4, OR2T10 and OR52M1. Here, we review the therapeutic potential of these 23 GPCRs, as well as 5‐HT
2A
and 5‐HT
7
, for ASD. For each GPCR, we discuss its genetic association, genetic and pharmacological manipulation in animal models, pharmacopoeia for core symptoms of ASD and rank them based on these factors. Among these GPCRs, we highlight D
2
, 5‐HT
2A
, CB
1
, OTR and V
1A
as the more promising targets for ASD. We discuss that the dysregulation of GPCRs and their signalling is a convergent pathological mechanism of ASD. Their therapeutic potential has only begun as multiple GPCRs could mitigate ASD. |
---|---|
AbstractList | Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein-coupled receptors (GPCRs) are the largest family of cellsurface receptors that transduce extracellular signals to convergent intracellular signalling and downstream cellular responses that are commonly dysregulated in ASD. Despite hundreds of GPCRs being expressed in the brain, only 23 are genetically associated with ASD according to the Simons Foundation Autism Research Initiative (SFARI) gene database: oxytocin OTR; vasopressin V 1A and V 1B ; metabotropic glutamate mGlu 5 and mGlu 7 ; GABA B2 ; dopamine D 1 , D 2 and D 3 ; serotoninergic 5-HT 1B ; β 2-adrenoceptor; cholinergic M 3 ; adenosine A 2A and A 3 ; angiotensin AT 2 ; cannabinoid CB 1 ; chemokine CX 3 CR1; orphan GPR37 and GPR85; and olfactory OR1C1, OR2M4, OR2T10 and OR52M1. Here, we review the therapeutic potential of these 23 GPCRs, as well as 5-HT 2A and 5-HT 7 , for ASD. For each GPCR, we discuss its genetic association, genetic and pharmacological manipulation in animal models, pharmacopoeia for core symptoms of ASD and rank them based on these factors. Among these GPCRs, we highlight D 2 , 5-HT 2A , CB 1 , OTR and V 1A as the more promising targets for ASD. We discuss that the dysregulation of GPCRs and their signalling is a convergent pathological mechanism of ASD. Their therapeutic potential has only begun as multiple GPCRs could mitigate ASD. Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling and downstream cellular responses that are commonly dysregulated in ASD. Despite hundreds of GPCRs being expressed in the brain, only 23 are genetically associated with ASD according to the Simons Foundation Autism Research Initiative (SFARI) gene database: oxytocin OTR; vasopressin V 1A and V 1B ; metabotropic glutamate mGlu 5 and mGlu 7 ; GABA B2 ; dopamine D 1 , D 2 and D 3 ; serotoninergic 5‐HT 1B ; β 2 ‐adrenoceptor; cholinergic M 3 ; adenosine A 2A and A 3 ; angiotensin AT 2 ; cannabinoid CB 1 ; chemokine CX 3 CR1; orphan GPR37 and GPR85; and olfactory OR1C1, OR2M4, OR2T10 and OR52M1. Here, we review the therapeutic potential of these 23 GPCRs, as well as 5‐HT 2A and 5‐HT 7 , for ASD. For each GPCR, we discuss its genetic association, genetic and pharmacological manipulation in animal models, pharmacopoeia for core symptoms of ASD and rank them based on these factors. Among these GPCRs, we highlight D 2 , 5‐HT 2A , CB 1 , OTR and V 1A as the more promising targets for ASD. We discuss that the dysregulation of GPCRs and their signalling is a convergent pathological mechanism of ASD. Their therapeutic potential has only begun as multiple GPCRs could mitigate ASD. |
Author | Crépieux, Pascale Annamneedi, Anil Bozon, Véronique Dudas, Ana Pellissier, Lucie P. Leray, Xavier Gora, Caroline |
Author_xml | – sequence: 1 givenname: Anil orcidid: 0000-0002-6743-8627 surname: Annamneedi fullname: Annamneedi, Anil organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France, LE STUDIUM Loire Valley Institute for Advanced Studies Orléans France, Department of Biotechnology, School of Bioengineering SRM Institute of Science and Technology Kattankulathur Tamil Nadu India – sequence: 2 givenname: Caroline surname: Gora fullname: Gora, Caroline organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France – sequence: 3 givenname: Ana surname: Dudas fullname: Dudas, Ana organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France – sequence: 4 givenname: Xavier orcidid: 0000-0003-2107-6082 surname: Leray fullname: Leray, Xavier organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France, Inria, Inria Saclay‐Ile‐de‐France Palaiseau France – sequence: 5 givenname: Véronique surname: Bozon fullname: Bozon, Véronique organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France – sequence: 6 givenname: Pascale orcidid: 0000-0002-2712-5271 surname: Crépieux fullname: Crépieux, Pascale organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France, Inria, Inria Saclay‐Ile‐de‐France Palaiseau France – sequence: 7 givenname: Lucie P. orcidid: 0000-0001-7085-3242 surname: Pellissier fullname: Pellissier, Lucie P. organization: Team Biology of GPCR Signaling Systems (BIOS), CNRS, IFCE, INRAE Université de Tours Nouzilly France |
BackLink | https://hal.science/hal-04220553$$DView record in HAL |
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CitedBy_id | crossref_primary_10_3390_biomedicines12071402 crossref_primary_10_3390_ijms25126521 crossref_primary_10_1016_j_neubiorev_2024_105686 |
Cites_doi | 10.1046/j.1365-2826.1997.t01-1-00589.x 10.1007/s10571-021-01064-9 10.1146/annurev-neuro-102320-102847 10.1007/164_2016_89 10.55782/ane-2010-1794 10.1176/ajp.2006.163.5.934 10.1186/s12862-020-01607-6 10.1038/npp.2015.66 10.1176/appi.books.9780890425596 10.1007/s00213-017-4586-9 10.1111/bph.15811 10.1038/npp.2015.196 10.1016/j.bbamem.2010.12.018 10.1007/PL00005484 10.1016/j.isci.2021.103655 10.1186/2040-2392-4-28 10.1016/S2215-0366(21)00429-6 10.1016/S0079-6123(08)00407-X 10.1016/j.coph.2014.11.004 10.3389/fnmol.2018.00250 10.1016/j.bbi.2015.05.009 10.1016/j.biopsych.2009.09.020 10.1177/13623613211034375 10.1111/gbb.12233 10.1002/ajmg.a.32275 10.1016/j.clinthera.2012.02.023 10.1134/S2079059717030157 10.1038/35065604 10.1210/me.2002-0222 10.1016/j.jaac.2015.04.005 10.1038/sj.npp.1300021 10.1016/j.phrs.2016.12.036 10.1186/s12864-016-2960-3 10.1016/j.xgen.2022.100250 10.1186/2040-2392-5-1 10.1016/j.pbb.2019.04.006 10.1111/j.1460-9568.2012.08180.x 10.1021/acs.jmedchem.7b00965 10.1007/s12035-017-0770-5 10.1007/s10802-015-0002-2 10.1038/npp.2014.105 10.1038/nn.3754 10.1111/j.1601-183X.2005.00118.x 10.1111/bph.15481 10.3109/10673220903523615 10.1038/s41586-020-2888-2 10.1093/cercor/bhv078 10.3389/fnint.2020.551676 10.1038/sj.npp.1300360 10.1210/me.2011-1267 10.1172/JCI127411 10.1038/nn.3641 10.1002/aur.1317 10.1021/acs.jmedchem.8b00697 10.1177/1179069518779829 10.1038/s41380-022-01506-w 10.1371/journal.pone.0145638 10.1530/JME-14-0009 10.1016/j.physbeh.2008.05.016 10.1038/nature10989 10.1016/S0165-5728(02)00033-4 10.1038/sj.mp.4001560 10.1016/bs.pmch.2020.03.001 10.1152/ajpendo.1988.254.1.E31 10.1016/j.biopsych.2010.12.022 10.1016/j.biopsych.2012.08.025 10.1002/aur.1901 10.1016/S0896-6273(00)80381-5 10.1016/j.yhbeh.2018.10.011 10.1016/j.biopsych.2010.03.014 10.1006/hbeh.1999.1566 10.1038/mp.2008.54 10.1016/bs.pmbts.2020.05.002 10.1038/77040 10.2174/0929867325666180313110254 10.1126/scitranslmed.aat7838 10.1073/pnas.0803081105 10.1152/physrev.00031.2017 10.1038/nrd.2017.178 10.1002/aur.2696 10.1186/s13229-015-0012-5 10.1016/j.neuroimage.2022.119243 10.1073/pnas.2118847119 10.1016/j.neures.2007.08.005 10.1016/j.neuropharm.2013.09.026 10.1073/pnas.0505312102 10.1016/j.neuropharm.2018.11.009 10.1210/en.2002-0197 10.3390/cells10112967 10.1016/j.braindev.2007.12.007 10.1111/gbb.12041 10.1016/j.bbr.2007.09.034 10.1111/bph.16057 10.1146/annurev-neuro-110920-023056 10.1016/0028-3908(95)00081-G 10.1111/gbb.12045 10.1152/physrev.00035.2011 10.1016/j.yhbeh.2011.10.007 10.1126/science.abk2055 10.1016/j.bbr.2021.113378 10.1016/j.yhbeh.2013.08.012 10.1016/j.neubiorev.2014.02.003 10.1111/ejn.13795 10.1111/j.1601-183X.2006.00281.x 10.1038/jcbfm.2011.133 10.1146/annurev.med.60.042307.110802 10.1038/sj.npp.1300008 10.1038/nature13772 10.1039/D0SC05501H 10.3389/fncel.2020.577858 10.1080/17460441.2019.1621285 10.1021/acs.jmedchem.1c00110 10.1172/jci.insight.143324 10.1016/j.neuroscience.2015.11.010 10.1007/s00213-021-05851-6 10.1111/j.1471-4159.2010.06858.x 10.1016/j.ejphar.2007.11.065 10.3389/fnmol.2018.00027 10.1016/j.bbamem.2011.02.007 10.1002/aur.1383 10.1073/pnas.0508063102 10.1016/j.jad.2017.08.041 10.1111/j.1476-5381.1992.tb09047.x 10.1016/j.cell.2017.11.033 10.1056/NEJMoa013171 10.1016/S0006-3223(00)01018-0 10.1073/pnas.0710717105 10.1126/scitranslmed.aai7459 10.1016/j.bbr.2006.12.009 10.1002/ana.25032 10.3390/jcm11040908 10.1038/s41386-021-01091-6 10.5607/en.2019.28.3.337 10.1007/s00726-012-1284-0 10.1016/j.bbr.2016.06.064 10.1093/molbev/msn294 10.1096/fj.10-175737 10.1002/ar.21299 10.1002/ajmg.a.30695 10.1176/appi.ajp.162.6.1142 10.1038/s41593-022-01177-4 10.1016/j.biopsych.2014.11.010 10.1186/s13229-023-00546-5 10.1038/sj.mp.4001404 10.1038/nature10110 10.1126/science.1123432 10.1542/peds.2015-1316 10.1056/NEJMoa2103583 10.1523/JNEUROSCI.21-20-08278.2001 10.1073/pnas.0914801107 10.1002/jnr.24560 10.1126/sciadv.1603001 10.1016/j.yhbeh.2011.10.010 10.1111/j.1365-2826.2012.02385.x 10.1186/s12868-021-00631-6 10.1186/2040-2392-4-15 10.1073/pnas.2121037119 10.1176/appi.ajp.158.7.1058 10.1038/s41386-022-01454-7 10.1073/pnas.0230374100 10.1176/appi.ajp.2020.20111608 10.1016/j.cell.2008.08.040 10.1016/j.pbb.2004.10.024 10.1038/s41593-019-0489-x 10.1080/10401230490452834 10.1371/journal.pone.0043030 10.3389/fnmol.2018.00353 10.1021/acs.jmedchem.9b01478 10.1176/appi.neuropsych.11080202 10.1016/j.neuron.2005.06.031 10.1037/0735-7044.113.3.587 10.1038/npp.2016.232 10.3389/fpsyt.2014.00067 10.1523/JNEUROSCI.2108-20.2021 10.1007/s00787-019-01333-5 10.1016/j.neulet.2006.12.054 10.1038/npp.2016.237 10.1007/s00213-006-0424-1 10.1016/j.neuron.2015.07.033 10.1021/bi9013775 10.1016/j.spen.2020.100834 10.1111/j.1601-183X.2012.00799.x 10.1016/j.neuron.2022.12.011 10.1111/jne.12363 10.1101/gr.178855.114 10.1126/scitranslmed.3004214 10.1038/tp.2017.207 10.1073/pnas.0910249107 10.1038/ncomms10884 10.1126/scitranslmed.3004218 10.3390/biomedicines10040796 10.1073/pnas.2102178118 10.1016/j.nlm.2016.06.020 10.7554/eLife.50519 10.1186/s13041-021-00769-8 10.1007/s10803-008-0604-4 10.1007/s11011-021-00699-3 10.1073/pnas.181356498 10.1073/pnas.0703368104 10.1542/peds.2008-3782 10.1016/j.cell.2019.12.036 10.1038/s41598-019-46268-8 10.1002/14651858.CD006996.pub2 10.1124/pr.110.002642 10.1126/scitranslmed.aau7356 10.1128/MCB.20.11.4106-4114.2000 10.1016/j.cell.2019.07.015 10.1007/s00213-013-3289-0 10.1126/scitranslmed.3001708 10.1002/mds.27457 10.1242/dmm.024752 10.1016/j.tips.2014.03.003 10.1111/j.1601-183X.2005.00119.x 10.1016/j.neuropharm.2007.11.005 10.1523/JNEUROSCI.1790-05.2005 10.1007/s12311-008-0075-3 10.1111/j.1460-9568.2004.03293.x 10.1100/tsw.2002.139 10.1021/acschemneuro.0c00647 10.1210/endrev/bnac032 10.1007/s11682-016-9604-8 10.2174/1381612821666150914121038 10.3389/fendo.2018.00017 10.1016/j.pnpbp.2014.04.013 10.1016/j.yhbeh.2022.105175 10.1097/00001756-200502280-00021 10.1111/jnc.13962 10.1097/YPG.0000000000000034 10.1002/glia.24053 10.1021/acschemneuro.0c00191 10.1002/cne.20601 10.1016/j.euroneuro.2014.02.004 10.1186/s13229-021-00420-2 10.1089/can.2015.0008 10.1038/nature10523 10.1186/s13229-020-00370-1 10.1111/gbb.12654 10.1126/scitranslmed.3010257 10.1371/journal.pone.0153667 |
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Keywords | social interaction G protein-coupled receptors signalling pathways autism spectrum disorder brain neurotransmitter |
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References | e_1_2_13_120_1 e_1_2_13_143_1 e_1_2_13_166_1 e_1_2_13_189_1 e_1_2_13_20_1 e_1_2_13_66_1 e_1_2_13_43_1 e_1_2_13_181_1 e_1_2_13_226_1 e_1_2_13_8_1 e_1_2_13_81_1 e_1_2_13_92_1 e_1_2_13_117_1 e_1_2_13_214_1 e_1_2_13_17_1 e_1_2_13_154_1 e_1_2_13_131_1 e_1_2_13_32_1 e_1_2_13_55_1 e_1_2_13_78_1 e_1_2_13_177_1 e_1_2_13_215_1 e_1_2_13_192_1 e_1_2_13_238_1 e_1_2_13_70_1 e_1_2_13_203_1 e_1_2_13_105_1 e_1_2_13_88_1 e_1_2_13_128_1 e_1_2_13_29_1 e_1_2_13_165_1 e_1_2_13_142_1 e_1_2_13_21_1 e_1_2_13_44_1 e_1_2_13_67_1 e_1_2_13_104_1 e_1_2_13_188_1 e_1_2_13_9_1 e_1_2_13_82_1 e_1_2_13_180_1 e_1_2_13_91_1 e_1_2_13_236_1 e_1_2_13_116_1 e_1_2_13_213_1 e_1_2_13_99_1 e_1_2_13_139_1 e_1_2_13_18_1 e_1_2_13_130_1 e_1_2_13_153_1 e_1_2_13_79_1 e_1_2_13_10_1 e_1_2_13_56_1 e_1_2_13_115_1 e_1_2_13_176_1 e_1_2_13_199_1 e_1_2_13_33_1 e_1_2_13_237_1 e_1_2_13_71_1 e_1_2_13_191_1 e_1_2_13_240_1 e_1_2_13_225_1 e_1_2_13_202_1 e_1_2_13_127_1 e_1_2_13_122_1 e_1_2_13_68_1 e_1_2_13_45_1 e_1_2_13_145_1 e_1_2_13_168_1 e_1_2_13_205_1 e_1_2_13_22_1 e_1_2_13_60_1 e_1_2_13_83_1 e_1_2_13_183_1 e_1_2_13_228_1 e_1_2_13_6_1 e_1_2_13_160_1 e_1_2_13_90_1 e_1_2_13_231_1 e_1_2_13_98_1 e_1_2_13_119_1 e_1_2_13_19_1 e_1_2_13_133_1 e_1_2_13_179_1 e_1_2_13_57_1 e_1_2_13_110_1 e_1_2_13_217_1 e_1_2_13_11_1 e_1_2_13_34_1 e_1_2_13_156_1 e_1_2_13_171_1 e_1_2_13_72_1 e_1_2_13_194_1 e_1_2_13_220_1 e_1_2_13_107_1 e_1_2_13_121_1 e_1_2_13_144_1 e_1_2_13_46_1 e_1_2_13_69_1 e_1_2_13_23_1 e_1_2_13_167_1 e_1_2_13_204_1 e_1_2_13_84_1 e_1_2_13_182_1 e_1_2_13_227_1 e_1_2_13_7_1 e_1_2_13_61_1 e_1_2_13_230_1 e_1_2_13_97_1 e_1_2_13_118_1 e_1_2_13_132_1 e_1_2_13_155_1 e_1_2_13_178_1 e_1_2_13_35_1 e_1_2_13_58_1 e_1_2_13_216_1 e_1_2_13_12_1 e_1_2_13_170_1 e_1_2_13_193_1 e_1_2_13_73_1 e_1_2_13_239_1 e_1_2_13_50_1 e_1_2_13_106_1 e_1_2_13_129_1 e_1_2_13_24_1 e_1_2_13_47_1 e_1_2_13_185_1 e_1_2_13_207_1 e_1_2_13_101_1 e_1_2_13_147_1 e_1_2_13_124_1 e_1_2_13_85_1 e_1_2_13_62_1 e_1_2_13_162_1 e_1_2_13_233_1 e_1_2_13_96_1 e_1_2_13_210_1 e_1_2_13_13_1 e_1_2_13_36_1 e_1_2_13_59_1 e_1_2_13_219_1 e_1_2_13_112_1 e_1_2_13_158_1 e_1_2_13_196_1 e_1_2_13_135_1 e_1_2_13_51_1 e_1_2_13_74_1 e_1_2_13_173_1 e_1_2_13_150_1 e_1_2_13_222_1 e_1_2_13_4_1 e_1_2_13_109_1 e_1_2_13_25_1 e_1_2_13_48_1 e_1_2_13_100_1 Zhou H. (e_1_2_13_241_1) 2020; 14 e_1_2_13_169_1 e_1_2_13_206_1 e_1_2_13_123_1 e_1_2_13_86_1 e_1_2_13_146_1 e_1_2_13_40_1 e_1_2_13_63_1 e_1_2_13_184_1 e_1_2_13_229_1 e_1_2_13_161_1 e_1_2_13_232_1 e_1_2_13_95_1 e_1_2_13_14_1 e_1_2_13_111_1 e_1_2_13_37_1 e_1_2_13_218_1 e_1_2_13_134_1 e_1_2_13_157_1 e_1_2_13_75_1 e_1_2_13_52_1 e_1_2_13_172_1 e_1_2_13_195_1 e_1_2_13_221_1 e_1_2_13_5_1 e_1_2_13_49_1 e_1_2_13_141_1 e_1_2_13_164_1 e_1_2_13_209_1 e_1_2_13_26_1 e_1_2_13_126_1 e_1_2_13_87_1 e_1_2_13_187_1 e_1_2_13_64_1 e_1_2_13_103_1 Kazek B. (e_1_2_13_108_1) 2010; 70 e_1_2_13_41_1 Alexander S. P. (e_1_2_13_3_1) 2021; 178 e_1_2_13_94_1 e_1_2_13_235_1 e_1_2_13_138_1 e_1_2_13_212_1 e_1_2_13_15_1 e_1_2_13_38_1 e_1_2_13_152_1 e_1_2_13_137_1 e_1_2_13_175_1 e_1_2_13_53_1 e_1_2_13_76_1 e_1_2_13_114_1 e_1_2_13_198_1 e_1_2_13_30_1 e_1_2_13_190_1 e_1_2_13_224_1 e_1_2_13_2_1 e_1_2_13_201_1 e_1_2_13_149_1 e_1_2_13_27_1 e_1_2_13_163_1 e_1_2_13_208_1 e_1_2_13_102_1 e_1_2_13_125_1 e_1_2_13_148_1 e_1_2_13_186_1 e_1_2_13_42_1 e_1_2_13_65_1 e_1_2_13_80_1 e_1_2_13_140_1 e_1_2_13_93_1 e_1_2_13_234_1 e_1_2_13_211_1 e_1_2_13_39_1 e_1_2_13_16_1 e_1_2_13_113_1 e_1_2_13_136_1 e_1_2_13_159_1 e_1_2_13_174_1 e_1_2_13_197_1 e_1_2_13_31_1 e_1_2_13_77_1 e_1_2_13_54_1 e_1_2_13_151_1 e_1_2_13_223_1 e_1_2_13_89_1 e_1_2_13_200_1 e_1_2_13_28_1 |
References_xml | – ident: e_1_2_13_50_1 doi: 10.1046/j.1365-2826.1997.t01-1-00589.x – ident: e_1_2_13_183_1 doi: 10.1007/s10571-021-01064-9 – ident: e_1_2_13_69_1 doi: 10.1146/annurev-neuro-102320-102847 – ident: e_1_2_13_175_1 doi: 10.1007/164_2016_89 – volume: 70 start-page: 232 year: 2010 ident: e_1_2_13_108_1 article-title: Platelet and intestinal 5‐HT2A receptor mRNA in autistic spectrum disorders—Results of a pilot study publication-title: Acta Neurobiologiae Experimentalis (Wars) doi: 10.55782/ane-2010-1794 contributor: fullname: Kazek B. – ident: e_1_2_13_159_1 doi: 10.1176/ajp.2006.163.5.934 – ident: e_1_2_13_168_1 doi: 10.1186/s12862-020-01607-6 – ident: e_1_2_13_202_1 doi: 10.1038/npp.2015.66 – ident: e_1_2_13_4_1 doi: 10.1176/appi.books.9780890425596 – ident: e_1_2_13_109_1 doi: 10.1007/s00213-017-4586-9 – ident: e_1_2_13_111_1 doi: 10.1111/bph.15811 – ident: e_1_2_13_172_1 doi: 10.1038/npp.2015.196 – ident: e_1_2_13_226_1 doi: 10.1016/j.bbamem.2010.12.018 – ident: e_1_2_13_65_1 doi: 10.1007/PL00005484 – ident: e_1_2_13_207_1 doi: 10.1016/j.isci.2021.103655 – ident: e_1_2_13_27_1 doi: 10.1186/2040-2392-4-28 – ident: e_1_2_13_98_1 doi: 10.1016/S2215-0366(21)00429-6 – ident: e_1_2_13_118_1 doi: 10.1016/S0079-6123(08)00407-X – ident: e_1_2_13_197_1 doi: 10.1016/j.coph.2014.11.004 – ident: e_1_2_13_101_1 doi: 10.3389/fnmol.2018.00250 – ident: e_1_2_13_32_1 doi: 10.1016/j.bbi.2015.05.009 – ident: e_1_2_13_78_1 doi: 10.1016/j.biopsych.2009.09.020 – ident: e_1_2_13_103_1 doi: 10.1177/13623613211034375 – ident: e_1_2_13_106_1 doi: 10.1111/gbb.12233 – ident: e_1_2_13_90_1 doi: 10.1002/ajmg.a.32275 – ident: e_1_2_13_219_1 doi: 10.1016/j.clinthera.2012.02.023 – ident: e_1_2_13_237_1 doi: 10.1134/S2079059717030157 – ident: e_1_2_13_233_1 doi: 10.1038/35065604 – ident: e_1_2_13_214_1 doi: 10.1210/me.2002-0222 – ident: e_1_2_13_58_1 doi: 10.1016/j.jaac.2015.04.005 – ident: e_1_2_13_91_1 doi: 10.1038/sj.npp.1300021 – ident: e_1_2_13_13_1 doi: 10.1016/j.phrs.2016.12.036 – ident: e_1_2_13_169_1 doi: 10.1186/s12864-016-2960-3 – ident: e_1_2_13_180_1 doi: 10.1016/j.xgen.2022.100250 – ident: e_1_2_13_41_1 doi: 10.1186/2040-2392-5-1 – ident: e_1_2_13_124_1 doi: 10.1016/j.pbb.2019.04.006 – ident: e_1_2_13_34_1 doi: 10.1111/j.1460-9568.2012.08180.x – ident: e_1_2_13_117_1 doi: 10.1021/acs.jmedchem.7b00965 – ident: e_1_2_13_121_1 doi: 10.1007/s12035-017-0770-5 – ident: e_1_2_13_204_1 doi: 10.1007/s10802-015-0002-2 – ident: e_1_2_13_45_1 doi: 10.1038/npp.2014.105 – ident: e_1_2_13_51_1 doi: 10.1038/nn.3754 – ident: e_1_2_13_186_1 doi: 10.1111/j.1601-183X.2005.00118.x – ident: e_1_2_13_185_1 doi: 10.1111/bph.15481 – ident: e_1_2_13_135_1 doi: 10.3109/10673220903523615 – ident: e_1_2_13_145_1 doi: 10.1038/s41586-020-2888-2 – ident: e_1_2_13_12_1 doi: 10.1093/cercor/bhv078 – volume: 14 year: 2020 ident: e_1_2_13_241_1 article-title: The role of microglial CX3CR1 in schizophrenia‐related behaviors induced by social isolation publication-title: Frontiers in Integrative Neuroscience doi: 10.3389/fnint.2020.551676 contributor: fullname: Zhou H. – ident: e_1_2_13_20_1 doi: 10.1038/sj.npp.1300360 – ident: e_1_2_13_160_1 doi: 10.1210/me.2011-1267 – ident: e_1_2_13_52_1 doi: 10.1172/JCI127411 – ident: e_1_2_13_238_1 doi: 10.1038/nn.3641 – ident: e_1_2_13_166_1 doi: 10.1002/aur.1317 – ident: e_1_2_13_68_1 doi: 10.1021/acs.jmedchem.8b00697 – ident: e_1_2_13_153_1 doi: 10.1177/1179069518779829 – ident: e_1_2_13_165_1 doi: 10.1038/s41380-022-01506-w – ident: e_1_2_13_240_1 doi: 10.1371/journal.pone.0145638 – ident: e_1_2_13_122_1 doi: 10.1530/JME-14-0009 – ident: e_1_2_13_164_1 doi: 10.1016/j.physbeh.2008.05.016 – ident: e_1_2_13_170_1 doi: 10.1038/nature10989 – ident: e_1_2_13_206_1 doi: 10.1016/S0165-5728(02)00033-4 – ident: e_1_2_13_239_1 doi: 10.1038/sj.mp.4001560 – ident: e_1_2_13_136_1 doi: 10.1016/bs.pmch.2020.03.001 – ident: e_1_2_13_57_1 doi: 10.1152/ajpendo.1988.254.1.E31 – ident: e_1_2_13_191_1 doi: 10.1016/j.biopsych.2010.12.022 – ident: e_1_2_13_9_1 doi: 10.1016/j.biopsych.2012.08.025 – ident: e_1_2_13_5_1 doi: 10.1002/aur.1901 – ident: e_1_2_13_134_1 doi: 10.1016/S0896-6273(00)80381-5 – ident: e_1_2_13_94_1 doi: 10.1016/j.yhbeh.2018.10.011 – ident: e_1_2_13_79_1 doi: 10.1016/j.biopsych.2010.03.014 – volume: 178 start-page: S27 issue: 1 year: 2021 ident: e_1_2_13_3_1 article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors publication-title: British Journal of Pharmacology contributor: fullname: Alexander S. P. – ident: e_1_2_13_230_1 doi: 10.1006/hbeh.1999.1566 – ident: e_1_2_13_150_1 doi: 10.1038/mp.2008.54 – ident: e_1_2_13_194_1 doi: 10.1016/bs.pmbts.2020.05.002 – ident: e_1_2_13_63_1 doi: 10.1038/77040 – ident: e_1_2_13_80_1 doi: 10.2174/0929867325666180313110254 – ident: e_1_2_13_22_1 doi: 10.1126/scitranslmed.aat7838 – ident: e_1_2_13_225_1 doi: 10.1073/pnas.0803081105 – ident: e_1_2_13_105_1 doi: 10.1152/physrev.00031.2017 – ident: e_1_2_13_83_1 doi: 10.1038/nrd.2017.178 – ident: e_1_2_13_236_1 doi: 10.1002/aur.2696 – ident: e_1_2_13_70_1 doi: 10.1186/s13229-015-0012-5 – ident: e_1_2_13_127_1 doi: 10.1016/j.neuroimage.2022.119243 – ident: e_1_2_13_56_1 doi: 10.1073/pnas.2118847119 – ident: e_1_2_13_96_1 doi: 10.1016/j.neures.2007.08.005 – ident: e_1_2_13_28_1 doi: 10.1016/j.neuropharm.2013.09.026 – ident: e_1_2_13_212_1 doi: 10.1073/pnas.0505312102 – ident: e_1_2_13_88_1 doi: 10.1016/j.neuropharm.2018.11.009 – ident: e_1_2_13_142_1 doi: 10.1210/en.2002-0197 – ident: e_1_2_13_156_1 doi: 10.3390/cells10112967 – ident: e_1_2_13_152_1 doi: 10.1016/j.braindev.2007.12.007 – ident: e_1_2_13_140_1 doi: 10.1111/gbb.12041 – ident: e_1_2_13_195_1 doi: 10.1016/j.bbr.2007.09.034 – ident: e_1_2_13_218_1 doi: 10.1111/bph.16057 – ident: e_1_2_13_133_1 doi: 10.1146/annurev-neuro-110920-023056 – ident: e_1_2_13_139_1 doi: 10.1016/0028-3908(95)00081-G – ident: e_1_2_13_129_1 doi: 10.1111/gbb.12045 – ident: e_1_2_13_112_1 doi: 10.1152/physrev.00035.2011 – ident: e_1_2_13_2_1 doi: 10.1016/j.yhbeh.2011.10.007 – ident: e_1_2_13_77_1 doi: 10.1126/science.abk2055 – ident: e_1_2_13_232_1 doi: 10.1016/j.bbr.2021.113378 – ident: e_1_2_13_53_1 doi: 10.1016/j.yhbeh.2013.08.012 – ident: e_1_2_13_43_1 doi: 10.1016/j.neubiorev.2014.02.003 – ident: e_1_2_13_10_1 doi: 10.1111/ejn.13795 – ident: e_1_2_13_229_1 doi: 10.1111/j.1601-183X.2006.00281.x – ident: e_1_2_13_102_1 doi: 10.1038/jcbfm.2011.133 – ident: e_1_2_13_15_1 doi: 10.1146/annurev.med.60.042307.110802 – ident: e_1_2_13_149_1 doi: 10.1038/sj.npp.1300008 – ident: e_1_2_13_48_1 doi: 10.1038/nature13772 – ident: e_1_2_13_49_1 doi: 10.1039/D0SC05501H – ident: e_1_2_13_24_1 doi: 10.3389/fncel.2020.577858 – ident: e_1_2_13_31_1 doi: 10.1080/17460441.2019.1621285 – ident: e_1_2_13_119_1 doi: 10.1021/acs.jmedchem.1c00110 – ident: e_1_2_13_66_1 doi: 10.1172/jci.insight.143324 – ident: e_1_2_13_158_1 doi: 10.1016/j.neuroscience.2015.11.010 – ident: e_1_2_13_188_1 doi: 10.1007/s00213-021-05851-6 – ident: e_1_2_13_167_1 doi: 10.1111/j.1471-4159.2010.06858.x – ident: e_1_2_13_210_1 doi: 10.1016/j.ejphar.2007.11.065 – ident: e_1_2_13_30_1 doi: 10.3389/fnmol.2018.00027 – ident: e_1_2_13_37_1 doi: 10.1016/j.bbamem.2011.02.007 – ident: e_1_2_13_203_1 doi: 10.1002/aur.1383 – ident: e_1_2_13_154_1 doi: 10.1073/pnas.0508063102 – ident: e_1_2_13_123_1 doi: 10.1016/j.jad.2017.08.041 – ident: e_1_2_13_199_1 doi: 10.1111/j.1476-5381.1992.tb09047.x – ident: e_1_2_13_84_1 doi: 10.1016/j.cell.2017.11.033 – ident: e_1_2_13_147_1 doi: 10.1056/NEJMoa013171 – ident: e_1_2_13_23_1 doi: 10.1016/S0006-3223(00)01018-0 – ident: e_1_2_13_146_1 doi: 10.1073/pnas.0710717105 – ident: e_1_2_13_75_1 doi: 10.1126/scitranslmed.aai7459 – ident: e_1_2_13_55_1 doi: 10.1016/j.bbr.2006.12.009 – ident: e_1_2_13_235_1 doi: 10.1002/ana.25032 – ident: e_1_2_13_211_1 doi: 10.3390/jcm11040908 – ident: e_1_2_13_224_1 doi: 10.1038/s41386-021-01091-6 – ident: e_1_2_13_120_1 doi: 10.5607/en.2019.28.3.337 – ident: e_1_2_13_196_1 doi: 10.1007/s00726-012-1284-0 – ident: e_1_2_13_6_1 doi: 10.1016/j.bbr.2016.06.064 – ident: e_1_2_13_46_1 doi: 10.1093/molbev/msn294 – ident: e_1_2_13_143_1 doi: 10.1096/fj.10-175737 – ident: e_1_2_13_60_1 doi: 10.1002/ar.21299 – ident: e_1_2_13_217_1 doi: 10.1002/ajmg.a.30695 – ident: e_1_2_13_148_1 doi: 10.1176/appi.ajp.162.6.1142 – ident: e_1_2_13_114_1 doi: 10.1038/s41593-022-01177-4 – ident: e_1_2_13_151_1 doi: 10.1016/j.biopsych.2014.11.010 – ident: e_1_2_13_42_1 doi: 10.1186/s13229-023-00546-5 – ident: e_1_2_13_25_1 doi: 10.1038/sj.mp.4001404 – ident: e_1_2_13_223_1 doi: 10.1038/nature10110 – ident: e_1_2_13_228_1 doi: 10.1126/science.1123432 – ident: e_1_2_13_73_1 doi: 10.1542/peds.2015-1316 – ident: e_1_2_13_201_1 doi: 10.1056/NEJMoa2103583 – ident: e_1_2_13_62_1 doi: 10.1523/JNEUROSCI.21-20-08278.2001 – ident: e_1_2_13_182_1 doi: 10.1073/pnas.0914801107 – ident: e_1_2_13_125_1 doi: 10.1002/jnr.24560 – ident: e_1_2_13_161_1 doi: 10.1126/sciadv.1603001 – ident: e_1_2_13_181_1 doi: 10.1016/j.yhbeh.2011.10.010 – ident: e_1_2_13_190_1 doi: 10.1111/j.1365-2826.2012.02385.x – ident: e_1_2_13_35_1 doi: 10.1186/s12868-021-00631-6 – ident: e_1_2_13_131_1 doi: 10.1186/2040-2392-4-15 – ident: e_1_2_13_213_1 doi: 10.1073/pnas.2121037119 – ident: e_1_2_13_177_1 doi: 10.1176/appi.ajp.158.7.1058 – ident: e_1_2_13_198_1 doi: 10.1038/s41386-022-01454-7 – ident: e_1_2_13_220_1 doi: 10.1073/pnas.0230374100 – ident: e_1_2_13_141_1 doi: 10.1176/appi.ajp.2020.20111608 – ident: e_1_2_13_187_1 doi: 10.1016/j.cell.2008.08.040 – ident: e_1_2_13_21_1 doi: 10.1016/j.pbb.2004.10.024 – ident: e_1_2_13_72_1 doi: 10.1038/s41593-019-0489-x – ident: e_1_2_13_137_1 doi: 10.1080/10401230490452834 – ident: e_1_2_13_59_1 doi: 10.1371/journal.pone.0043030 – ident: e_1_2_13_39_1 doi: 10.3389/fnmol.2018.00353 – ident: e_1_2_13_200_1 doi: 10.1021/acs.jmedchem.9b01478 – ident: e_1_2_13_18_1 doi: 10.1176/appi.neuropsych.11080202 – ident: e_1_2_13_19_1 doi: 10.1016/j.neuron.2005.06.031 – ident: e_1_2_13_26_1 doi: 10.1037/0735-7044.113.3.587 – ident: e_1_2_13_216_1 doi: 10.1038/npp.2016.232 – ident: e_1_2_13_38_1 doi: 10.3389/fpsyt.2014.00067 – ident: e_1_2_13_205_1 doi: 10.1523/JNEUROSCI.2108-20.2021 – ident: e_1_2_13_138_1 doi: 10.1007/s00787-019-01333-5 – ident: e_1_2_13_85_1 doi: 10.1016/j.neulet.2006.12.054 – ident: e_1_2_13_221_1 doi: 10.1038/npp.2016.237 – ident: e_1_2_13_192_1 doi: 10.1007/s00213-006-0424-1 – ident: e_1_2_13_163_1 doi: 10.1016/j.neuron.2015.07.033 – ident: e_1_2_13_54_1 doi: 10.1021/bi9013775 – ident: e_1_2_13_17_1 doi: 10.1016/j.spen.2020.100834 – ident: e_1_2_13_93_1 doi: 10.1111/j.1601-183X.2012.00799.x – ident: e_1_2_13_14_1 doi: 10.1016/j.neuron.2022.12.011 – ident: e_1_2_13_174_1 doi: 10.1111/jne.12363 – ident: e_1_2_13_95_1 doi: 10.1101/gr.178855.114 – ident: e_1_2_13_16_1 doi: 10.1126/scitranslmed.3004214 – ident: e_1_2_13_128_1 doi: 10.1038/tp.2017.207 – ident: e_1_2_13_7_1 doi: 10.1073/pnas.0910249107 – ident: e_1_2_13_234_1 doi: 10.1038/ncomms10884 – ident: e_1_2_13_87_1 doi: 10.1126/scitranslmed.3004218 – ident: e_1_2_13_29_1 doi: 10.3390/biomedicines10040796 – ident: e_1_2_13_209_1 doi: 10.1073/pnas.2102178118 – ident: e_1_2_13_44_1 doi: 10.1016/j.nlm.2016.06.020 – ident: e_1_2_13_115_1 doi: 10.7554/eLife.50519 – ident: e_1_2_13_110_1 doi: 10.1186/s13041-021-00769-8 – ident: e_1_2_13_76_1 doi: 10.1007/s10803-008-0604-4 – ident: e_1_2_13_130_1 doi: 10.1007/s11011-021-00699-3 – ident: e_1_2_13_33_1 doi: 10.1073/pnas.181356498 – ident: e_1_2_13_144_1 doi: 10.1073/pnas.0703368104 – ident: e_1_2_13_171_1 doi: 10.1542/peds.2008-3782 – ident: e_1_2_13_193_1 doi: 10.1016/j.cell.2019.12.036 – ident: e_1_2_13_47_1 doi: 10.1038/s41598-019-46268-8 – ident: e_1_2_13_184_1 doi: 10.1002/14651858.CD006996.pub2 – ident: e_1_2_13_11_1 doi: 10.1124/pr.110.002642 – ident: e_1_2_13_173_1 doi: 10.1126/scitranslmed.aau7356 – ident: e_1_2_13_104_1 doi: 10.1128/MCB.20.11.4106-4114.2000 – ident: e_1_2_13_189_1 doi: 10.1016/j.cell.2019.07.015 – ident: e_1_2_13_99_1 doi: 10.1007/s00213-013-3289-0 – ident: e_1_2_13_100_1 doi: 10.1126/scitranslmed.3001708 – ident: e_1_2_13_74_1 doi: 10.1002/mds.27457 – ident: e_1_2_13_92_1 doi: 10.1242/dmm.024752 – ident: e_1_2_13_157_1 doi: 10.1016/j.tips.2014.03.003 – ident: e_1_2_13_82_1 doi: 10.1111/j.1601-183X.2005.00119.x – ident: e_1_2_13_126_1 doi: 10.1016/j.neuropharm.2007.11.005 – ident: e_1_2_13_113_1 doi: 10.1523/JNEUROSCI.1790-05.2005 – ident: e_1_2_13_61_1 doi: 10.1007/s12311-008-0075-3 – ident: e_1_2_13_81_1 doi: 10.1111/j.1460-9568.2004.03293.x – ident: e_1_2_13_97_1 doi: 10.1100/tsw.2002.139 – ident: e_1_2_13_116_1 doi: 10.1021/acschemneuro.0c00647 – ident: e_1_2_13_222_1 doi: 10.1210/endrev/bnac032 – ident: e_1_2_13_86_1 doi: 10.1007/s11682-016-9604-8 – ident: e_1_2_13_132_1 doi: 10.2174/1381612821666150914121038 – ident: e_1_2_13_215_1 doi: 10.3389/fendo.2018.00017 – ident: e_1_2_13_178_1 doi: 10.1016/j.pnpbp.2014.04.013 – ident: e_1_2_13_231_1 doi: 10.1016/j.yhbeh.2022.105175 – ident: e_1_2_13_155_1 doi: 10.1097/00001756-200502280-00021 – ident: e_1_2_13_208_1 doi: 10.1111/jnc.13962 – ident: e_1_2_13_89_1 doi: 10.1097/YPG.0000000000000034 – ident: e_1_2_13_179_1 doi: 10.1002/glia.24053 – ident: e_1_2_13_40_1 doi: 10.1021/acschemneuro.0c00191 – ident: e_1_2_13_162_1 doi: 10.1002/cne.20601 – ident: e_1_2_13_71_1 doi: 10.1016/j.euroneuro.2014.02.004 – ident: e_1_2_13_8_1 doi: 10.1186/s13229-021-00420-2 – ident: e_1_2_13_227_1 doi: 10.1089/can.2015.0008 – ident: e_1_2_13_107_1 doi: 10.1038/nature10523 – ident: e_1_2_13_36_1 doi: 10.1186/s13229-020-00370-1 – ident: e_1_2_13_67_1 doi: 10.1111/gbb.12654 – ident: e_1_2_13_176_1 doi: 10.1126/scitranslmed.3010257 – ident: e_1_2_13_64_1 doi: 10.1371/journal.pone.0153667 |
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Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and... Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and... |
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Title | Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders |
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