Proliferation Effects on Hair Growth of Compounds Isolated from the Bark of Dalbergia oliveri

One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Us...

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Published inNatural product communications Vol. 12; no. 11
Main Authors Park, Seon Ju, Nhiem, Nguyen Xuan, Tai, Bui Huu, Le Tuan Anh, Hoang, Oh, Seok Hyun, Sung, Jong-Hyuk, Kim, Nanyoung, Yoo, Guijae, Park, Jun Hyung, Kwak, Hee Jae, Loan, Pham Thanh, Kim, Seung Hyun, Van Kiem, Phan
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.11.2017
Subjects
Isoflavane
Proliferation effect
Hair growth
Dalbergia oliveri
Fabaceae
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Summary:One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5’-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1701201117