Arousal-Related Reticular Neurons during Reduced Oxygen Tension: Resilience and Recovery of Electrical Activity

Whole-cell patch clamp recordings of the electrical activity of large medullary reticular formation neurons, in nucleus gigantocellularis, were performed under control conditions and under conditions of hypoxia or anoxia. Neurons were discovered whose activity was remarkably resilient during and aft...

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Published inDevelopmental neuroscience Vol. 31; no. 4; pp. 255 - 258
Main Authors Zhou, J., Kow, L.-M., Vannucci, S.J., Pfaff, D.W., Martin, E.M.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2009
Subjects
Action Potentials - physiology
Animals
Arousal
Arousal - physiology
Female
Hypoxia - metabolism
Mice
Neurons - cytology
Neurons - physiology
Oxygen - metabolism
Patch-Clamp Techniques
Pregnancy
Reticular Formation - cytology
Reticular Formation - physiology
Reticular formation
Patch clamp
Hypoxia
Neonate
Anoxia
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Summary:Whole-cell patch clamp recordings of the electrical activity of large medullary reticular formation neurons, in nucleus gigantocellularis, were performed under control conditions and under conditions of hypoxia or anoxia. Neurons were discovered whose activity was remarkably resilient during and after the reduction or loss of oxygen. Such cells may relate to the ability of the newborn brain to survive hypoxia/anoxia, and also may demonstrate the preservation of neurons involved in generalized CNS arousal, as would be appropriate for activating behavioral responses to the reduction or loss of oxygen.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISBN:3805592396
9783805592390
ISSN:0378-5866
1421-9859
DOI:10.1159/000216536