An all-purpose tool for axon guidance

The functions of the 75-kilodalton neurotrophin receptor p75(NTR) have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75(NTR) is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing...

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Bibliographic Details
Published inScience signaling Vol. 1; no. 47; p. pe50
Main Authors Schecterson, Leslayann C, Bothwell, Mark
Format Journal Article
LanguageEnglish
Published United States 25.11.2008
Subjects
Animals
Axons - ultrastructure
Humans
Receptor, Nerve Growth Factor - physiology
Signal Transduction
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Summary:The functions of the 75-kilodalton neurotrophin receptor p75(NTR) have remained enigmatic despite nearly three decades of study. Recent studies reveal that p75(NTR) is a versatile co-receptor that controls signaling by receptors for multiple ligands that provide repellant guidance cues to developing axons.
ISSN:1937-9145
DOI:10.1126/scisignal.147pe50