Structure-activity relationships of some pyrethroids in rats

The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and...

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Bibliographic Details
Published inArchives of toxicology Vol. 45; no. 4; pp. 325 - 329
Main Authors Verschoyle, R.D, Aldridge, W.N
Format Journal Article
LanguageEnglish
Published Germany 01.10.1980
Subjects
Animals
Behavior, Animal - drug effects
Female
Injections, Intravenous
Pyrethrins - toxicity
Rats
Stereoisomerism
Structure-Activity Relationship
toxicity
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Summary:The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and burrowing behaviour, salivation, coarse tremor, progressing to sinuous writhing (choreoathetosis) and clonic seizures. The two exceptions presented a TS-syndrome with salivation associated with the T-syndrome. No clearcut relationship between chemical structure and symptoms of poisoning has emerged through some generalisations are discussed.
ISSN:0340-5761
1432-0738
DOI:10.1007/bf00293813