Short and efficient preparations of isoxazole-3-carboxylic acid and imino-oxopentanoic acid potent precursors of 4-hydroxyisoleucine
Herein, we describe short and efficient syntheses of isoxazole-3-carboxylic acid 3a and imino-oxopentanoic acid 8 achiral precursors of 4-hydroxyisoleucine. The developed procedures involve readily available and cheap starting materials and can easily be transposed to the large scale. Graphical Abst...
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Published in | Tetrahedron Vol. 62; no. 18; pp. 4430 - 4434 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
01.05.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Herein, we describe short and efficient syntheses of isoxazole-3-carboxylic acid
3a
and imino-oxopentanoic acid
8
achiral precursors of 4-hydroxyisoleucine. The developed procedures involve readily available and cheap starting materials and can easily be transposed to the large scale.
Graphical Abstract |
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2006.02.056 |