Lower nonword syllable sequence repetition accuracy in adults who stutter is related to differences in audio-motor oscillations

• Published in: Neuropsychologia Vol. 199; p. 108906
• Main Authors: Bowers, Andrew, Hudock, Daniel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 04.07.2024
• Subjects: Event-related desynchronization; Event-related spectral perturbations; Event-related synchronization; Independent component analysis; Phonological working memory; Event-related spectral perturbations; Event-related desynchronization; Phonological working memory; Event-related synchronization; Independent component analysis
• ISSN: 0028-3932; 1873-3514; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2024.108906

The goal of this study was to use independent component analysis (ICA) of high-density electroencephalography (EEG) to investigate whether differences in audio-motor neural oscillations are related to nonword syllable repetition accuracy in a group of adults who stutter compared to typically fluent speakers. EEG was recorded using 128 channels from 23 typically fluent speakers and 23 adults who stutter matched for age, sex, and handedness. EEG was recorded during delayed, 2 and 4 bilabial nonword syllable repetition conditions. Scalp-topography, dipole source estimates, and power spectral density (PSD) were computed for each independent component (IC) and used to cluster similar ICs across participants. Event-related spectral perturbations (ERSPs) were computed for each IC cluster to examine changes over time in the repetition conditions and to examine how dynamic changes in ERSPs are related to syllable repetition accuracy. Findings indicated significantly lower accuracy on a measure of percentage correct trials in the AWS group and for a normalized measure of syllable load performance across conditions. Analysis of ERSPs revealed significantly lower alpha/beta ERD in left and right μ ICs and in left and right posterior temporal lobe α ICs in AWS compared to TFS (CC p < 0.05). Pearson correlations with %CT for frequency across time showed strong relationships with accuracy (FWE<0.05) during maintenance in the TFS group and during execution in the AWS group. Findings implicate lower alpha/beta ERD (8–30 Hz) during syllable encoding over posterior temporal ICs and execution in left temporal/sensorimotor components. Strong correlations with accuracy and interindividual differences in ∼6–8 Hz ERSPs during execution implicate differences in motor and auditory-sensory monitoring during syllable sequence execution in AWS. •Adults who stutter were less accurate on a delayed, nonword syllable sequence repetition task.•Lower alpha/beta ERD and theta/alpha oscillations were related to behavioral accuracy in AWS.•Findings implicate differences sensorimotor integration in AWS during nonword syllable processing, maintenance, and execution.