Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 14; no. 5; pp. 1133 - 1137
• Main Authors: YU, Kuo-Long, YI ZHANG, CIANCI, Christopher W, KRYSTAL, Mark, MEANWELL, Nicholas A, CIVIELLO, Rita L, TREHAN, A. Ashok K, PEARCE, Bradley C, ZHIWEI YIN, COMBRINK, Keith D, GULGEZE, H. Belgin, WANG, Xiangdong Alan, KADOW, Kathleen F
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 08.03.2004
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Benzimidazoles - chemistry; Benzimidazoles - pharmacology; Biological and medical sciences; Medical sciences; Pharmacology. Drug treatments; Respiratory Syncytial Viruses - drug effects; Respiratory Syncytial Viruses - physiology; Human respiratory syncytial virus; Pneumovirinae; Nitrogen heterocycle; In vitro; Paramyxoviridae; Virus; Mononegavirales; Structure activity relation; Benzimidazole derivatives; Bicyclic compound; Antiviral; Ureas; Aromatic compound; Pneumovirus; Chemical synthesis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2003.12.072

Structure-activity relationships for a series of benzimidazol-2-one-based inhibitors of respiratory syncytial virus are described. These studies focused on structural variation of the benzimidazol-2-one substituent, a vector inaccessible in a series of benzotriazole derivatives on which 2 is based, and revealed a broad tolerance for substituent size and functionality.