Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population

• Published in: Diabetes care Vol. 12; no. 10; pp. 701 - 708
• Main Authors: Gay, E C, Hamman, R F, Carosone-Link, P J, Lezotte, D C, Cook, M, Stroheker, R, Klingensmith, G, Chase, H P
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.1989
• Subjects: Adolescent; Age Factors; Child; Child, Preschool; Colorado; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - epidemiology; Ethnic Groups; Female; Hispanic Americans; Humans; Incidence; Infant; Male; Registries; Sex Factors; Surveys and Questionnaires; Colorado
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.12.10.701

Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population. E C Gay , R F Hamman , P J Carosone-Link , D C Lezotte , M Cook , R Stroheker , G Klingensmith and H P Chase Department of Preventive Medicine, University of Colorado School of Medicine, Denver 80262. Abstract The Colorado IDDM Registry identifies newly diagnosed cases of insulin-dependent diabetes mellitus (IDDM) throughout the state. Hispanics in Colorado are a racial mixture of American Indian and White populations. Because American Indians have a low risk of IDDM, and differing frequencies of HLA antigens and haplotypes are reported for Hispanics and non-Hispanics, we compared incidence rates and disease characteristics. Eligible participants were less than 18 yr of age and Colorado residents at time of diagnosis, diagnosed between 1 January 1978 and 31 December 1983, and on insulin within 2 wk of diagnosis. Subjects were reported by their physicians, and statewide validation of reporting was conducted through review of hospital discharge indexes. Incidence rates for Hispanics (n = 76) were significantly lower than those for non-Hispanics (n = 628), although 95% confidence intervals overlapped for children aged 10-17 yr. Age-adjusted rates were significantly lower in Hispanic than non-Hispanic males, whereas age-adjusted rates for females did not differ. The cumulative risk of IDDM was less for Hispanic males aged 0-17 yr than for non-Hispanic males (P less than .001); cumulative risk among females was males (P less than .001); cumulative risk among females was not different (P = .10). Clinical onset characteristics and medical care at diagnosis were similar. After diagnosis, hospitalizations per 100 person-yr appeared higher in Hispanics, but ketoacidosis and insulin reactions per 100 person-yr were similar. Difference in rate of hospitalizations may have been due to lower response rates among older non-Hispanics.