Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population
Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population. E C Gay , R F Hamman , P J Carosone-Link , D C Lezotte , M Cook , R Stroheker , G Klingensmith and H P Chase Department of Preventive Medicine, University of...
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Published in | Diabetes care Vol. 12; no. 10; pp. 701 - 708 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.11.1989
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Subjects | |
Online Access | Get full text |
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Summary: | Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic
population.
E C Gay ,
R F Hamman ,
P J Carosone-Link ,
D C Lezotte ,
M Cook ,
R Stroheker ,
G Klingensmith and
H P Chase
Department of Preventive Medicine, University of Colorado School of Medicine, Denver 80262.
Abstract
The Colorado IDDM Registry identifies newly diagnosed cases of insulin-dependent diabetes mellitus (IDDM) throughout the state.
Hispanics in Colorado are a racial mixture of American Indian and White populations. Because American Indians have a low risk
of IDDM, and differing frequencies of HLA antigens and haplotypes are reported for Hispanics and non-Hispanics, we compared
incidence rates and disease characteristics. Eligible participants were less than 18 yr of age and Colorado residents at time
of diagnosis, diagnosed between 1 January 1978 and 31 December 1983, and on insulin within 2 wk of diagnosis. Subjects were
reported by their physicians, and statewide validation of reporting was conducted through review of hospital discharge indexes.
Incidence rates for Hispanics (n = 76) were significantly lower than those for non-Hispanics (n = 628), although 95% confidence
intervals overlapped for children aged 10-17 yr. Age-adjusted rates were significantly lower in Hispanic than non-Hispanic
males, whereas age-adjusted rates for females did not differ. The cumulative risk of IDDM was less for Hispanic males aged
0-17 yr than for non-Hispanic males (P less than .001); cumulative risk among females was males (P less than .001); cumulative
risk among females was not different (P = .10). Clinical onset characteristics and medical care at diagnosis were similar.
After diagnosis, hospitalizations per 100 person-yr appeared higher in Hispanics, but ketoacidosis and insulin reactions per
100 person-yr were similar. Difference in rate of hospitalizations may have been due to lower response rates among older non-Hispanics. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.12.10.701 |